Review Paper

The Diversity of Long Noncoding RNAs and Their Generation

Long noncoding RNAs (lncRNAs) are emerging as potential key regulators in gene expression networks and exhibit a surprising range of shapes and sizes. Several distinct classes of lncRNAs are transcribed from different DNA elements, including promoters, enhancers, and intergenic regions in eukaryotic genomes. Additionally, others are derived from long primary transcripts with noncanonical RNA processing pathways, generating new RNA species ...

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LncRNA Transcriptional Control of Inflammatory Responses

lncRNA

Long non-coding RNAs (lncRNAs) have emerged as potential key regulators of the inflammatory response, particularly by modulating the transcriptional control of inflammatory genes. LncRNAs may act as an enhancer or suppressor to inflammatory transcription, function as scaffold molecules through interactions with RNA-binding proteins in chromatin remodeling complexes, and modulate dynamic and epigenetic control of inflammatory transcription in a gene-specific and ...

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Linc-ing the Noncoding Genome to Heart Function

lncrna

Cardiovascular disease is a major health concern worldwide. Hypertensive stress, inflammation or injury of heart muscle, and abnormal rhythms due to valve dysfunction can contribute to the enlargement of cardiac cells known as ‘pathological’ hypertrophy. Pathological hypertrophy can further lead to fibrosis or scarring of tissue, reduced capillary densities, increased levels of proinflammatory cytokines, dysregulation of signaling pathways, autophagy, and ...

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The prognostic value of long noncoding RNAs in prostate cancer

lncRNA

The abnormally expressed LncRNAs played irreplaceable roles in the prognosis of prostate cancer (PCa). Therefore, researchers from Wuhan University conducted this systematic review and meta-analysis to summarize the association between the expression of LncRNAs, prognosis and clinicopathology of PCa. 18 eligible studies were recruited into their analysis, including 18 on prognosis and 9 on clinicopathological features. Results indicated that aberrant ...

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A Review of Recent Computational Methods for Predicting Noncoding RNAs

lncrna

Noncoding RNAs (ncRNAs) play important roles in various cellular activities and diseases. Researchers from Hebei University of Science and Technology, present a comprehensive review on computational methods for ncRNA prediction, which are generally grouped into four categories: (1) homology-based methods, that is, comparative methods involving evolutionarily conserved RNA sequences and structures, (2) de novo methods using RNA sequence and structure features, ...

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Transcriptional and Post-transcriptional Gene Regulation by Long Non-coding RNA

lncRNA

Advances in genomics technology over recent years have led to the surprising discovery that the genome is far more pervasively transcribed than was previously appreciated. Much of the newly-discovered transcriptome appears to represent long non-coding RNA (lncRNA), a heterogeneous group of largely uncharacterised transcripts. Understanding the biological function of these molecules represents a major challenge and researchers from the University of ...

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LINC00152 – A pivotal oncogenic long non-coding RNA in human cancers

lncRNA

In recent years, increasing evidence has shown the potential role of long non-coding RNAs (lncRNAs) in multiple cancers. Deregulation of lncRNAs was detected being closely associated with many kinds of tumours where they can act as a tumour suppressor or accelerator. LINC00152 was identified as an oncogene involved in many kinds of cancers, such as gastric cancer, hepatocellular carcinoma, colon ...

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Long noncoding RNA – a crosslink in biological regulatory network

lncRNA

Long noncoding RNAs (lncRNAs) had been defined as a novel class of functional RNAs longer than 200 nucleotides around a decade ago. It is widely acknowledged that lncRNAs play a significant role in regulation of gene expression, but the biological and molecular mechanisms are diverse and complex, and remain to be determined. Especially, the regulatory network of lncRNAs associated with ...

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Present Scenario of Long Non-Coding RNAs in Plants

lncRNA

Small non-coding RNAs have been extensively studied in plants over the last decade. In contrast, genome-wide identification of plant long non-coding RNAs (lncRNAs) has recently gained momentum. LncRNAs are now being recognized as important players in gene regulation, and their potent regulatory roles are being studied comprehensively in eukaryotes. LncRNAs were first reported in humans in 1992. Since then, research ...

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Perspectives of long non-coding RNAs in cancer

lncRNA

A recent advance in transcriptomics has spawned the ‘Decade of non-coding RNAs’ by potentiating the growing numbers of long non-coding RNA in cancer. LncRNA involvement in cancer denotes its significance beyond our perception as they participate in tumor suppression and promoting oncogenesis, which raises them as a mighty class of effectors or regulators. Aberrantly expressed lncRNAs interact with major protein ...

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