Review Paper

Challenges in the analysis of long noncoding RNA functionality

lncRNA

Long noncoding RNAs (lncRNAs) are emerging as important regulators of diverse biological functions. Although mechanistic models are starting to emerge, it is also clear that the lncRNA field needs appropriate model systems in order to better elucidate the functions of lncRNAs and their roles in both physiological and pathological conditions. The field of lncRNAs is new, and the biochemical and ...

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Role of long non-coding RNA in tumor drug resistance

lncRNA

Chemotherapy has been extensively used in tumor treatment, including either systemic or local treatment. Miserably, in many kinds of cancers, chemotherapy is gradually insensitive. The mechanisms of tumor drug resistance have been widely explored, yet have not been fully characterized. With several studies in the development of drug resistance, recent works have highlighted the involvement of non-coding RNAs in tumor ...

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Long non-coding RNA regulation of liver cancer stem cell self-renewal offers new therapeutic targeting opportunities

lncRNA

Long non-coding RNAs (lncRNA) are critical regulators of gene expression, and can reprogram the transcriptome to modulate cellular processes involved in cellular growth and differentiation, and thereby contribute to tumorigenesis. In addition to effects on tumor cell growth, survival and cell signaling, lncRNA can modulate cancer stem cell (CSC) behavior, including the expression of pluripotency factors. The identification of lncRNA ...

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Cancer subtypes classification using long non-coding RNA

lncRNA

Inter-tumor heterogeneity might explain divergent clinical evolution of cancers bearing similar pathological features. In the last decade, genomic has highly improved tumor subtypes classification through the identification of oncogenic or tumor suppressor drivers. In addition, epigenetics and long non-coding RNAs (lncRNAs) are emerging as new fields for investigation, which might also account for tumor heterogeneity. There is growing evidence that ...

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Long noncoding RNAs as novel predictors of survival in human cancer

lncRNA

Expression of various long noncoding RNAs (lncRNAs) may affect cancer prognosis. Researchers from Stanford University examined all evidence on the potential role of lncRNAs as novel predictors of survival in human cancer. The researchers systematically searched through PubMed, to identify all published studies reporting on the association between any individual lncRNA or group of lncRNAs with prognosis in human cancer ...

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Long non-coding RNA – computational models

lncRNA

LncRNAs have attracted lots of attentions from researchers worldwide in recent decades. With the rapid advances in both experimental technology and computational prediction algorithm, thousands of lncRNA have been identified in eukaryotic organisms ranging from nematodes to humans in the past few years. More and more research evidences have indicated that lncRNAs are involved in almost the whole life cycle ...

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Deciphering the function of non-coding RNAs in prostate cancer

lncRNA

The advent of next-generation sequencing methods is fuelling the discovery of multiple non-coding RNA transcripts with direct implication in cell biology and homeostasis. This new layer of biological regulation seems to be of particular importance in human pathogenesis, including cancer. The aberrant expression of ncRNAs is a feature of prostate cancer, as they promote tumor-suppressive or oncogenic activities, controlling multicellular ...

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Is there a link between long noncoding RNAs and depression?

lncrna

The major depressive disorder (MDD) is a relatively common mental disorder from which that hundreds of million people have suffered, leading to displeasing life quality, which is characterized by health damage and even suicidal thoughts. The complicated development and functioning of MDD is still under exploration. Long noncoding RNA (lncRNAs) are highly expressed in the brain, could affect neural stem ...

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Long Noncoding RNAs – Central to Nervous System Development

lncRNA

The development of the central nervous system (CNS) is a complex orchestration of stem cells, transcription factors, growth/differentiation factors, and epigenetic control. Noncoding RNAs have been identified, classified, and studied for their functional roles in many systems including the CNS. In particular, the class of long noncoding RNAs (lncRNAs) has generated both enthusiasm and skepticism due to the unexpected discovery, ...

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Targeting a Long Noncoding RNA in Breast Cancer

lncRNA

The central dogma of molecular biology posits that genes are transcribed into messenger RNA (mRNA), which is then translated into proteins, which, in turn, are ultimately responsible for all cellular functions. Yet recent research has revealed that RNAs that do not encode proteins — known as noncoding RNAs — play important roles in normal physiological processes and can contribute to ...

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