Publications

Identification of an lncRNA‑miRNA‑mRNA interaction mechanism in breast cancer

lncRNA

Non‑coding RNAs serve important roles in regulating the expression of certain genes and are involved in the principal biological processes of breast cancer. The majority of studies have focused on defining the regulatory functions of long non‑coding RNAs (lncRNAs) and microRNAs (miRNAs/miRs), and few studies have investigated how lncRNAs and miRNAs are transcriptionally regulated. In the present study, based on ...

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Identification and characterization of a long non-coding RNA up-regulated during HIV-1 infection

lncRNA

Long non-coding RNAs (lncRNAs) are rapidly emerging as important regulators of a diverse array of cellular functions. Here, Columbia University researchers describe a meta-analysis of two independent RNA-seq studies to identify lncRNAs that are differentially expressed upon HIV-1 infection. Only three lncRNA genes exhibited altered expression of ≥ 2-fold in HIV-1-infected cells. Of these, the uncharacterized lncRNA LINC00173 was chosen ...

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Two novel lncRNAs discovered in human mitochondrial DNA using PacBio full-length transcriptome data

lncrna

In this study, researchers at Nankai University introduced a general framework to use PacBio full-length transcriptome sequencing for the investigation of mitochondrial RNAs. As a result, they produced the first full-length human mitochondrial transcriptome based on the public PacBio data and characterized the human mitochondrial transcriptome with more comprehensive and accurate information. Other results included the determination of the H-strand ...

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Identification of key lncRNAs in colorectal cancer progression based on associated protein–protein interaction analysis

lncRNA

Colorectal cancer (CRC) was one of the most commonly diagnosed malignancies. The molecular mechanisms involved in the progression of CRC remain unclear. Accumulating evidences showed that long noncoding RNAs (lncRNAs) played key roles in tumorigenesis, cancer progression, and metastasis. Researchers at Fudan University aimed to explore the roles of lncRNAs in the progression of CRC. In this study, the researchers aimed to ...

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Researchers hypothesize that the prostate-specific lncRNA PCA3 has been introduced into the human genome by an ancient virus

Prostate cancer, the most frequent type of cancer in men, is surpassed only by lung cancer in causing cancer-related death. Despite major progress in defining the mutational landscape of this tumor, its etiology remains obscure. The intronic long-noncoding RNA (lncRNA) PCA3 is a specific marker of prostate cancer that acts as a trans-dominant negative oncogene to down-regulate the tumor suppressor ...

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Plasma lncRNA HOTAIR could serve as a promising biomarker for diagnosing and monitoring NSCLC

lncrna

Long noncoding RNA (LncRNA) homeotic genes (HOX) transcript antisense RNA (HOTAIR) has been reported to play a vital role in various cancers. It has been found that HOTAIR was upregulated in non-small cell lung cancer (NSCLC) and involved in cell invasion and metastasis. The aberrant expression of HOTAIR is expected to serve as a potential biomarker for patients with NSCLC. ...

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Microarray expression profiling of long non-coding RNAs in epithelial ovarian cancer

lncRNA

Although numerous long non-coding RNAs (lncRNAs) have been identified to be important in human cancer, their potential regulatory roles in epithelial tumorigenesis and tumor progression in ovarian cancer remain unclear. Researchers from Nanjing Medical University set out to investigate lncRNAs that were differentially expressed (DE) in epithelial ovarian cancer and to explore their potential functions. The lncRNA profiles in five pairs ...

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Targeting long non-coding RNA DANCR inhibits triple negative breast cancer progression

lncRNA

Triple negative breast cancer (TNBC) is non-responsive to conventional anti-hormonal and Her2 targeted therapies, making it necessary to identify new molecular targets for therapy. Long non-coding RNA anti-differentiation ncRNA (lncRNA DANCR) was identified in participating carcinogenesis of hepatocellular carcinoma, but its expression and potential role in TNBC progression is still unclear. In the present study, Researchers from Peking University Health Science ...

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Comprehensive discovery of non-coding RNAs in acute myeloid leukemia cell transcriptomes

lncRNA

To comprehensively detect diverse and novel RNA species, researchers from Washington University, St. Louis compared deep small RNA and RNA sequencing (RNA-seq) methods applied to a primary acute myeloid leukemia (AML) sample. They were able to discover previously unannotated small RNAs using deep sequencing of a library method employing broader insert size selection. The researchers analyzed the long non-coding RNA (lncRNA) ...

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lncRNA GAS5 and the efficacy of steroids

lncRNA

Glucocorticoids (GCs) are widely employed in inflammatory, autoimmune and neoplastic diseases, and, despite the introduction of novel therapies, remain the first-line treatment for inducing remission in inflammatory bowel disease (IBD). Given the high incidence of suboptimal response, associated with a significant number of side effects, that are particularly severe in paediatric patients, the identification of subjects that are most likely ...

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