Publications

Microarray profiling identifies long noncoding RNAs functionally involved in neurogenesis

lncRNA

The denervated hippocampus provides a proper microenvironment for the survival and neuronal differentiation of neural progenitors. While thousands of lncRNAs were identified, only a few lncRNAs that regulate neurogenesis in the hippocampus are reported. Researchers from Nantong University aimed to perform microarray expression profiling to identify long noncoding RNAs (lncRNAs) that might participate in the hippocampal neurogenesis, and investigate the potential ...

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Identification and validation long non-coding RNAs of oral squamous cell carcinoma by bioinformatics method

lncRNA

Gene markers of oral squamous cell carcinoma (OSCC) have great significance on early diagnosis and treatment of clinical oral cancer. In this study, researchers from the Children Hospital of Chongqing Medical University used RNA-Seq data from OSCC patients and filtered differentially-expressed long non-coding RNA (lncRNA) to further clarify the molecular mechanism. First, they downloaded datasets of OSCC from National Center ...

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The lncRNA AK144841 could contribute to molecular cascades leading to tumor development

lncRNA

Keratinocyte-derived cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer. Although some of the early events involved in this pathology have been identified, the subsequent steps leading to tumor development are poorly defined. Researchers from Universite Cote d Azur demonstrate here that the development of mouse tumors induced by the concomitant application of a carcinogen and a ...

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Long Noncoding RNA Moderates MicroRNA Activity to Maintain Self-Renewal in Embryonic Stem Cells

lncrna

Of the thousands of long noncoding RNAs expressed in embryonic stem cells (ESCs), few have known roles and fewer have been functionally implicated in the regulation of self-renewal and pluripotency, or the reprogramming of somatic cells to the pluripotent state. In ESCs, Cyrano is a stably expressed long intergenic noncoding RNA with no previously assigned role. Researchers from the University ...

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Panel of seven long noncoding RNA as a candidate prognostic biomarker for ovarian cancer

lncRNA

Ovarian cancer is one of the most common and lethal gynecological malignancies. The diagnosis of ovarian cancer is often at an advanced stage. Accumulated evidence suggests that long noncoding RNAs (lncRNAs) play important roles during ovarian tumorigenesis. In this study, using the lncRNA-mining approach, researchers from the Chinese Academy of Sciences and Fudan University analyzed lncRNA expression profiles of 493 ...

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Global ID of lncRNAs associated with insecticide resistance in diamondback moths

Long noncoding RNAs (lncRNAs) are now considered important regulatory factors, with a variety of biological functions in many species including insects. Some lncRNAs have the ability to show rapid responses to diverse stimuli or stress factors and are involved in responses to insecticide. However, there are no reports to date on the characterization of lncRNAs associated with chlorantraniliprole resistance in ...

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Researchers identify cancer-related long noncoding RNAs in quintuple-negative lung adenocarcinoma

lncRNA

Lung adenocarcinoma (LUAD) is a common subtype of non-small cell lung cancer prevalent in Asia. There is a dearth of understanding regarding the transcriptome landscape of LUAD without primary known driver mutations. In this study, researchers at MSD China R&D used LUAD samples without well-known driver mutations occurring in EGFR, KRAS, ALK, ROS1 or RET (quintuple-negative) for transcriptome study with ...

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Targeting long non-coding RNA ASBEL with oligonucleotide antagonist for breast cancer therapy

lncrna

Long non-coding RNAs (lncRNAs) are defined as a class of RNA transcripts longer than 200 nucleotides encoded by mammalian genomes that lack protein-coding potential. LncRNA ASBEL has been identified as an anti-sense transcript of BTG3 (B cell translocation gene 3) gene, which encodes an anti-proliferation protein. Remarkable down-regulation of BTG3 has been reported in triple-negative breast cancer (TNBC). In the ...

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lncRNA SNHG6 is a Potential Biomarker for Hepatocellular Carcinoma

lncRNA

Long Non-coding RNAs (lncRNAs) refer to all non-protein coding transcripts longer than 200 nucleotides. Their critical roles in different biological pathways have been already well established. Altered expression of lncRNAs can be involved in the cancer initiation and/or progression. Since patients with hepatocellular carcinoma (HCC) are usually diagnosed in late stages, developing diagnostic methods seems to be essential. In this ...

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The novel long intergenic noncoding RNA UCC promotes colorectal cancer

lncRNA

The human genome contains thousands of long intergenic noncoding RNAs (lincRNAs). However, the functional roles of these transcripts and the mechanisms responsible for their deregulation in colorectal cancer (CRC) remain elusive. Researchers at Sun Yat-sen University found a novel lincRNA termed upregulated in CRC (UCC) was highly expressed in human CRC tissues and cell lines. UCC levels correlated with lymph node ...

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