Publications

lncRNA-HIT promotes cell proliferation of non-small cell lung cancer

Lung cancer is the leading cause of cancer-related death around the world. Long noncoding RNA (lncRNA) has pivotal roles in cancer occurrence and development. However, only a few lncRNAs have been functionally characterized. Jilin University researchers investigated the effects of lncRNA-HIT (HOXA transcript induced by TGFβ) expression on non-small cell lung cancer (NSCLC) cell phenotype with the gain-of-function and loss-of-function ...

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The lncRNome of head and neck squamous cell carcinomas

Long non-coding RNAs (lncRNAs) have emerged as key players in a remarkably variety of biological processes and pathologic conditions, including cancer. Next-generation sequencing technologies and bioinformatics procedures predict the existence of tens of thousands of lncRNAs, from which we know the functions of only a handful of them, and very little is known in cancer types such as head and ...

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De novo RNA sequence assembly during in vivo inflammatory stress reveals hundreds of unannotated lincRNAs in human blood

lncrna

Long intergenic noncoding RNAs (lincRNAs) have emerged as key regulators of cellular functions and physiology. Yet functional lincRNAs often have low, context-specific and tissue-specific expression. Researchers from Columbia University Medical Center hypothesized that many human monocyte and adipose lincRNAs would be absent in current public annotations due to lincRNA tissue specificity, modest sequencing depth in public data, limitations of transcriptome assembly ...

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Novel lincRNA SLINKY is a prognostic biomarker in kidney cancer

lncRNA

Clear cell renal cell carcinomas (ccRCC) show a broad range of clinical behavior, and prognostic biomarkers are needed to stratify patients for appropriate management. Stanford University researchers  sought to determine whether long intergenic non-coding RNAs (lincRNAs) might predict patient survival. Candidate prognostic lincRNAs were identified by mining The Cancer Genome Atlas (TCGA) transcriptome (RNA-seq) data on 466 ccRCC cases (randomized ...

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Development of a novel prognostic signature of long non-coding RNAs in lung adenocarcinoma

lncRNA

Increasing evidence suggests that long non-coding RNAs (lncRNAs) may play a crucial role in many biological processes in a variety of cancers and serve as the basis for many clinical applications including prognostic biomarkers and potential therapeutic targets. Researchers from the Fudan University Shanghai Cancer Center set out to develop a prognostic lncRNA signature with RNA-seq data in lung adenocarcinomas. ...

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Flicr, a long noncoding RNA, modulates Foxp3 expression and autoimmunity

lncRNA

A combination of transcription factors, enhancers, and epigenetic marks determines the expression of the key transcription factor FoxP3 in regulatory T cells (Tregs). Adding an additional layer of complexity, the long noncoding RNA (lncRNA) Flicr (Foxp3 long intergenic noncoding RNA) is a negative regulator that tunes Foxp3 expression, resulting in a subset of Tregs with twofold- to fivefold-lower levels of ...

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Long Noncoding RNA MANTIS Facilitates Endothelial Angiogenic Function

lncRNA

The angiogenic function of endothelial cells is regulated by numerous mechanisms but the impact of long noncoding RNAs (lncRNAs) has hardly been studied. Goethe-University researchers set out to identify novel and functionally important endothelial lncRNAs. Epigenetically controlled lncRNAs in human umbilical vein endothelial cells (HUVEC) were searched by exon-array analysis after knockdown of the histone demethylase JARID1B. Molecular mechanisms were ...

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Impact of Dietary Interventions on Noncoding RNA Networks

lncRNA

Dietary interventions dramatically affect metabolic disease and lifespan in various aging models. Here, researchers from the Shanghai Institutes for Biological Sciences profiled liver microRNA (miRNA), coding, and long non-coding RNA (lncRNA) expression by high-throughput deep sequencing in mice across multiple energy intake and expenditure interventions. Strikingly, three dietary intervention network design patterns were uncovered: (1) lifespan-extending interventions largely repressed the ...

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Seven LncRNA-mRNA based risk score predicts the survival of head and neck squamous cell carcinoma

lncrna

Dysregulation of mRNAs and long non-coding RNAs (lncRNAs) is one of the most important features of carcinogenesis and cancer development. However, studies integrating the expression of mRNAs and lncRNAs to predict the survival of head and neck squamous cell carcinoma (HNSC) are still limited, hitherto. In current work, researchers at the Zhejiang University School of medicine identified survival related mRNAs ...

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An atlas and analysis of bovine skeletal muscle long noncoding RNAs

lncRNA

Long noncoding RNAs (lncRNAs) have various biological functions and have been extensively studied in recent years. However, the identification and characterization of bovine lncRNAs in skeletal muscle has been very limited compared with that of lncRNAs in other model organisms. In this study, researchers from Tianjin Agricultural University identified 7188 bovine skeletal muscle lncRNAs in four different muscle tissues by ...

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