Publications

Identification of transposable elements contributing to tissue-specific expression of long non-coding RNAs

lncrna

It has been recently suggested that transposable elements (TEs) are re-used as functional elements of long non-coding RNAs (lncRNAs). This is supported by some examples such as the human endogenous retrovirus subfamily H (HERVH) elements contained within lncRNAs and expressed specifically in human embryonic stem cells (hESCs), as required to maintain hESC identity. There are at least two unanswered questions ...

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Researchers use CRISPR to show that the short splicing isoform of Xist RNA is sufficient to induce X-chromosome inactivation

lncRNA

Alternative splicing of mRNA precursors results in multiple protein variants from a single gene and is critical for diverse cellular processes and development. Xist encodes a long noncoding RNA which is a central player to induce X-chromosome inactivation in female mammals and has two major splicing variants: long and short isoforms of Xist RNA. Although a differentiation-specific and a female-specific ...

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Profiling long noncoding RNA of multi-tissue transcriptome enhances porcine noncoding genome annotation

lncRNA

To construct a comprehensive pig noncoding transcriptome and further enhance porcine noncoding genome annotation, researchers at China Agricultural University performed tissue-based long noncoding RNA (lncRNA) profiling. They identified 32,212 nonredundant lncRNA isoforms corresponding to 18,676 lncRNA loci across 34 normal pig tissues using high-throughput sequencing. Furthermore, they globally assessed the potential relationship between these identified lncRNAs and known protein-coding genes ...

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Genome-wide identification of long non-coding RNA genes and their association with insecticide resistance

lncRNA

Long non-coding RNA (lncRNA) is a class of noncoding RNA >200 bp in length that has essential roles in regulating a variety of biological processes. Here, researchers from Yichun University constructed a computational pipeline to identify lncRNA genes in the diamondback moth (Plutella xylostella), a major insect pest of cruciferous vegetables. In total, 3,324 lncRNAs corresponding to 2,475 loci were identified ...

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