Technology

Presentation – REGULATION OF CHROMATIN STRUCTURE BY NONCODING RNA

DANESH MOAZED: “REGULATION OF CHROMATIN STRUCTURE BY NONCODING RNA” (CELLULAR DYNAMICS RESEARCH TALKS) Date/Time Tue, 4/9/2013, 11:45 a.m. – 1 p.m. Location Biolabs Lecture Hall 1080, 16 Divinity Ave. Description “Regulation of chromatin structure by noncoding RNA”Danesh Moazed, Ph.D. Professor of Cell Biology, Harvard Medical School HHMI Investigator https://moazed.med.harvard.edu/ Abstract: Noncoding RNAs play central roles in the assembly of repressive ...

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MALAT1 – a paradigm for long noncoding RNA function in cancer

MALAT1

The metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a bona fide long noncoding RNA (lncRNA). MALAT1, also known as nuclear-enriched transcript 2 (NEAT2), was discovered as a prognostic marker for lung cancer metastasis but also has been linked to several other human tumor entities. Recent work established a critical regulatory function of this lncRNA in lung cancer metastasis and cell ...

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Long Noncoding RNA MALAT1 Controls Cell Cycle Progression

MALAT1

The mammalian genome encodes large number of long non protein-coding RNAs (lncRNAs). These lncRNAs are suggested to regulate key biological processes (including cellular proliferation and differentiation), and aberrant expression of these is associated with cancer. However, only a few of these lncRNAs have been functionally validated in biological or disease processes. MALAT1, an abundant nuclear-retained lncRNA, is overexpressed in several ...

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Long noncoding RNAs: new players in the molecular mechanism for maintenance and differentiation of pluripotent stem cells

Stem Cells

Maintenance of the pluripotent state or differentiation of the pluripotent state into any germ layer depend on factors that orchestrate expression of thousands of genes through epigenetic, transcriptional and post transcriptional regulation. Long noncoding RNAs (lncRNAs) are implicated in the complex molecular circuitry in developmental processes. The ENCODE project has opened up new avenues for studying these lncRNA transcripts with ...

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The roles of long noncoding RNA in epigenetic regulation

epigenetics & chromatin

Oral Presentation – from Epigenetics and Chromatin: Interactions and processes, Boston, MA, USA. 11-13 March 2013 The X-linked region now known as the ‘X-inactivation center’ (Xic) was once dominated by protein-coding genes but, with the rise of Eutherian mammals some 150-200 million years ago, became infiltrated by genes that produce long noncoding RNA (lncRNA). Some of the noncoding genes have ...

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Non-Coding RNAs as Potential Neuroprotectants against Ischemic Brain Injury

brain injury

Over the past decade, scientific discoveries have highlighted new roles for a unique class of non-coding RNAs. Transcribed from the genome, these non-coding RNAs have been implicated in determining the biological complexity seen in mammals by acting as transcriptional and translational regulators. Non-coding RNAs, which can be sub-classified into long non-coding RNAs, microRNAs, PIWI-interacting RNAs and several others, are widely ...

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Featured Product – Knockdown and detection of lncRNA

Lincode

Thermo Scientific Lincode siRNA and Solaris lncRNA Expression Assays Comprehensive pre-designed reagents for investigation of human lncRNAs siRNAs with enhanced specificity from the RNAi leaders High-efficiency qPCR assays for specific and dependable lncRNA detection Lincode siRNAs have been created to support the growing interest in analysis of long noncoding RNAs (lncRNA). As with siGENOME and ON-TARGETplus siRNAs, which target protein-coding ...

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