Press Release

lnRNA discovery could help boost plant heat, drought tolerance

Texas A&M AgriLife Research scientists have discovered a ribonucleic acid, or RNA, that can increase the thale cress plant’s resistance to stress from drought and salt. The discovery could help illuminate a new pathway to engineering drought- and salt-tolerant plants, including food crops, said Dr. Liming Xiong, AgriLife Research associate professor, Dallas. The research is published in the journal Plant ...

Read More »

Long, mysterious strips of RNA contribute to low sperm count

lncRNA

Scientists at Case Western Reserve University School of Medicine have found distinctive portions of genetic material–known as lncRNAs–that help sperm develop. Male mice lacking a particular lncRNA have low sperm count, suggesting lncRNAs could represent novel infertility drug targets. “Infertility affects 10 to 15 percent of couples in the United States, with the vast majority of cases due to unknown ...

Read More »

MUSC researchers show how long non-coding RNA promotes tumor formation

A mechanism that pushes a certain gene to produce a non-coding form of RNA instead of its protein-coding alternative can promote the growth of cancer, report researchers at the Medical University of South Carolina (MUSC) in an article published online ahead of print on August 21, 2017 by Nature Cell Biology. The non-coding RNA soaks up a microRNA that prevents epithelial-to-mesenchymal ...

Read More »

Researchers Show Curcumin Protects Against Chemoresistant Pancreatic Cancer Through lncRNA

lncRNA

Curcumin is known for its powerful anti-inflammatory and antioxidant benefits, but a new study by researchers at Baylor Scott & White Research Institute reveals an additional benefit: its potential to overcome chemoresistance in pancreatic ductal adenocarcinoma (PDAC), a common but aggressive form of cancer in the pancreas. The study, “Curcumin sensitizes pancreatic cancer cells to gemcitabine by attenuating PRC2 subunit ...

Read More »

lncRNA researcher at Stanford Medicine named Outstanding Investigator by the National Cancer Institute

lncRNA

The National Cancer Institute has named professor of dermatology HOWARD CHANG, MD as a recipient of the institute’s Outstanding Investigator Awards for 2016. Howard Chang The awards provide funding to investigators with outstanding records of productivity in cancer research. Recipients receive up to $600,000 each year for seven years to pursue or extend research projects of unusual potential. “This is a ...

Read More »

Targeting lncRNA to reduce heart failure in pulmonary hypertension

lncrna

An article published in Experimental Biology and Medicine identifies a new signaling pathway that promotes heart failure in pulmonary hypertension.  The study, led by Dr. Matthias Brock, from the Division of Pulmonology, University Hospital of Zurich, University of Zurich in Switzerland, reports that inhibition of MALAT1, a long noncoding RNA, reduces heart hypertrophy in mice with pulmonary hypertension. Pulmonary hypertension ...

Read More »

New tool predicts the interaction of proteins and RNA

CRG Researchers developed Global Score, a method that allows, for the first time, to predict protein interactions with long non-coding RNAs. This algorithm helps scientists prioritize binding partners for experimental validation, which will contribute to our understanding of the role of long non-coding RNAs in normal cell function and in disease. Far from just reading the information contained in the ...

Read More »

IQuity lands $150K NIH grant for autoimmune disease research

exosomes

Nashville-based IQuity — which analyzes RNA data to develop tools that help physicians diagnose autoimmune diseases — has received a $150,000 grant from the National Institutes of Health’s Small Business Innovation Research program. The grant will help fund IQuity’s ongoing research into long non-coding RNAs and their usefulness in distinguishing fibromyalgia from rheumatic diseases including rheumatoid arthritis and lupus, according ...

Read More »

UCSF CRISPR Study Reveals Unexpected Roles of Long Non-Coding RNAs

lncRNA

High-Throughput Screening Platform Finds that Distinct Non-Coding RNAs are Essential to the Growth of Different Cancer Cell Types UC San Francisco researchers have taken a major step toward understanding the function of the tens of thousands of human genes that do not code for proteins, a phenomenon considered one of the key remaining mysteries of the human genome. New findings ...

Read More »

Human natural antisense lncRNAs can up-regulate protein translation

lncRNA

One of the biggest surprises of the past decade of genomic studies was the discovery that, contrary to previous belief, the majority of the genome is not used to produce proteins. Initially, many scientists thought that these long non-coding RNAs were non-functional “noise,” but in recent studies, a growing fraction of these lncRNAs have been found to have regulatory functions. ...

Read More »