Press Release

Targeting lncRNA to reduce heart failure in pulmonary hypertension

lncrna

An article published in Experimental Biology and Medicine identifies a new signaling pathway that promotes heart failure in pulmonary hypertension.  The study, led by Dr. Matthias Brock, from the Division of Pulmonology, University Hospital of Zurich, University of Zurich in Switzerland, reports that inhibition of MALAT1, a long noncoding RNA, reduces heart hypertrophy in mice with pulmonary hypertension. Pulmonary hypertension ...

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New tool predicts the interaction of proteins and RNA

CRG Researchers developed Global Score, a method that allows, for the first time, to predict protein interactions with long non-coding RNAs. This algorithm helps scientists prioritize binding partners for experimental validation, which will contribute to our understanding of the role of long non-coding RNAs in normal cell function and in disease. Far from just reading the information contained in the ...

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IQuity lands $150K NIH grant for autoimmune disease research

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Nashville-based IQuity — which analyzes RNA data to develop tools that help physicians diagnose autoimmune diseases — has received a $150,000 grant from the National Institutes of Health’s Small Business Innovation Research program. The grant will help fund IQuity’s ongoing research into long non-coding RNAs and their usefulness in distinguishing fibromyalgia from rheumatic diseases including rheumatoid arthritis and lupus, according ...

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UCSF CRISPR Study Reveals Unexpected Roles of Long Non-Coding RNAs

lncRNA

High-Throughput Screening Platform Finds that Distinct Non-Coding RNAs are Essential to the Growth of Different Cancer Cell Types UC San Francisco researchers have taken a major step toward understanding the function of the tens of thousands of human genes that do not code for proteins, a phenomenon considered one of the key remaining mysteries of the human genome. New findings ...

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Human natural antisense lncRNAs can up-regulate protein translation

lncRNA

One of the biggest surprises of the past decade of genomic studies was the discovery that, contrary to previous belief, the majority of the genome is not used to produce proteins. Initially, many scientists thought that these long non-coding RNAs were non-functional “noise,” but in recent studies, a growing fraction of these lncRNAs have been found to have regulatory functions. ...

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CSHL scientists test an antisense method of targeting long noncoding RNAs overexpressed in breast cancers

lncRNAs

The human body produces 100,000 or more different proteins. Yet, amazingly, only two percent of the human genome actually encodes proteins. Nearly 80 percent of the rest of the genome is transcribed into RNA that does not code for proteins. Two big questions facing scientists are: How much of this “non-coding” RNA is actually functional? And does it play a ...

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lncRNA DINO essential to DNA damage response

lncRNA

Stanford researchers have found that a tumor suppressor known as p53 is stabilized by a regulatory lncRNA molecule called DINO. The interaction helps a cell respond to DNA damage and may play a role in cancer development and premature aging. p53-mediated induction of DINO in turn stabilizes p53 through RNA–protein interaction, amplifying DNA damage response. Knowing when to hold them, ...

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lncRNAs Maintain Equilibrium Between Fighting Infection, Inflammatory Havoc

lncRNA

Penn Study Identifies New Drug Target for Inflammatory Disorders PHILADELPHIA – Special RNA molecules called long non-coding RNAs (lncRNAs) are key controllers for maintaining immune health when fighting infection or preventing inflammatory disorders, according to research led by Jorge Henao-Mejia, MD, PhD, an assistant professor of Pathology and Laboratory Medicine in the Perelman School of Medicine at the University of ...

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Long non-coding RNA a potential therapeutic target for certain inflammatory disorders

lncRNA

A long non-coding RNA, Morrbid, controls how long circulating myeloid cells live, which is key to maintaining the proper balance between fighting infection and exacerbating inflammation. The discovery offers a potential therapeutic target for certain inflammatory disorders, such as asthma, Churg-Strauss syndrome and hypereosinophilic syndrome, that are characterized by abnormal myeloid cell lifespan. Circulating myeloid cells (neutrophils, eosinophils and so-called “classical” ...

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Long noncoding RNA found to quell inflammation

lncRNA

UMass Medical School researchers implicate lincRNA in immune system A long noncoding RNA (lincRNA)—called lincRNA-EPS—responsible for regulating innate immunity has been identified by a team of scientists at UMass Medical School. The findings were published in Cell. Katherine A. Fitzgerald, PhD, professor of medicine, is senior author on the study. Abundantly found in macrophages, lincRNA-EPS keeps the genes that trigger ...

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