Commentary

lncRNAs take center stage at NCI RNA Biology 2017 symposium

rna-seq

The recent discovery of new classes of RNAs and the demonstration that alterations in RNA metabolism underlie numerous human cancers have resulted in enormous interest among CCR investigators in RNA Biology. In order to share the latest research in this exciting field, the CCR Initiative in RNA Biology held its second international symposium April 23-24, 2017, in Natcher Auditorium. With ...

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Could long non-coding RNAs be used as biomarkers for urothelial carcinoma?

exosomes

Bioanalysis Zone – Amy Craddock, Future Science Group – Collaborative research from medical faculties across Germany and Hungary has investigated the potential use of long non-coding RNAs as diagnostic and prognostic biomarkers for urothelial carcinoma. In previous studies, it has been identified that a number of long non-coding RNAs are overexpressed in urothelial carcinoma; as a result it has been ...

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Translating the ribosome’s grim role

A large number of long noncoding RNAs (lncRNA) have been found associating with the ribosome, the protein-making machinery in the cytoplasm. What the so-called ‘noncoding’ RNAs are doing on the ribosome, whose main job is to translate RNA into protein, has puzzled the A*STAR researchers who discovered them. The answer could be macabre, suggest cell biologist, Leah Vardy, at the ...

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Linking lncRNA to autoimmune diseases

lncRNA

News Medical Life Sciences – An interview with Dr. Chase Spurlock, CEO, IQuity, conducted by April Cashin-Garbutt, MA (Cantab) What are long non-coding RNAs (lncRNAs) and how do they differ from messenger RNAs (mRNAs)? Well, the central dogma of biology states that DNA makes RNA and RNA makes proteins. However, there are many different types of RNAs, and only one ...

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Dietary anti-cancer compound may work by influence over lncRNAs

lncRNA

Researchers have discovered one of the reasons why broccoli may be good for your health.  They found that sulforaphane, a dietary compound from broccoli that’s known to help prevent prostate cancer, may work through its influence on long, non-coding RNAs. This is another step forward in a compelling new area of study on the underlying genetics of cancer development and ...

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Comprehensive Atlas of Long Noncoding RNAs Yields Surprising New Role

The FANTOM5 project reports nearly 20,000 functional lncRNAs in human Genetic Engineering News – The Central Dogma of molecular biology states that DNA encodes RNA, RNA encodes protein. While this process is certainly true for the vast majority gene regulatory functions, in recent years, scientists have discovered that this is by no means an exclusive process. In fact, studies examining ...

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New tool predicts the interaction of proteins and RNA

CRG Researchers developed Global Score, a method that allows, for the first time, to predict protein interactions with long non-coding RNAs. This algorithm helps scientists prioritize binding partners for experimental validation, which will contribute to our understanding of the role of long non-coding RNAs in normal cell function and in disease. Far from just reading the information contained in the ...

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Researchers at Imperial College London have found that so-called ‘junk DNA’ could play a role in diabetes

lncrna

The human genome is enormous, containing billions of ‘letters’ of genetic code. But among the thousands of genes which code for vital proteins, hidden in plain sight are much vaster chunks of non-coding junk DNA, previously thought to have no function. Shining the spotlight on these dark, unexplored regions of the genome, an international team led by scientists at Imperial ...

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CRISPR-Mediated Interference (CRISPRi) of Long Non-Coding RNA (lncRNA)

lncRNA

by Jerry Zon More Methodology from CRISPR Mania lncRNA Function Blocked by CRISPRi Mysteries of lncRNA Can Now be Deciphered by CRISPRi This blog is about yet another example of a powerful new methodology spawned by intense scientific interest in using CRISPR-related technologies. This near mania for all things CRISPR is reflected by there being ~5,000 (!) publications already in ...

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A “coding” long non-coding RNA

lncRNA

from Genetic Engineering News Although long noncoding RNAs (lncRNAs) are by definition noncoding, they are known to encode disproportionately short molecules—mere polypeptides, not proteins. Whether these polypeptides matter very much is another question. They could represent nothing more than transcriptional noise, or they could be—as a new study suggests—functionally relevant. In the new study, scientists based at Beth Israel Deaconess ...

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