Commentary

Researchers at Imperial College London have found that so-called ‘junk DNA’ could play a role in diabetes

lncrna

The human genome is enormous, containing billions of ‘letters’ of genetic code. But among the thousands of genes which code for vital proteins, hidden in plain sight are much vaster chunks of non-coding junk DNA, previously thought to have no function. Shining the spotlight on these dark, unexplored regions of the genome, an international team led by scientists at Imperial ...

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CRISPR-Mediated Interference (CRISPRi) of Long Non-Coding RNA (lncRNA)

lncRNA

by Jerry Zon More Methodology from CRISPR Mania lncRNA Function Blocked by CRISPRi Mysteries of lncRNA Can Now be Deciphered by CRISPRi This blog is about yet another example of a powerful new methodology spawned by intense scientific interest in using CRISPR-related technologies. This near mania for all things CRISPR is reflected by there being ~5,000 (!) publications already in ...

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A “coding” long non-coding RNA

lncRNA

from Genetic Engineering News Although long noncoding RNAs (lncRNAs) are by definition noncoding, they are known to encode disproportionately short molecules—mere polypeptides, not proteins. Whether these polypeptides matter very much is another question. They could represent nothing more than transcriptional noise, or they could be—as a new study suggests—functionally relevant. In the new study, scientists based at Beth Israel Deaconess ...

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Of the RNAs expressed at different levels in the autism brains, 60 are long non-coding RNAs

exosome

from Spectrum News by Nicholette Zeliadt The brains of people with autism show a distinct molecular signature, according to the largest-yet postmortem study of people with the condition1. The signature reflects alterations in how genes are pieced together and expressed. The findings confirm and extend those from two smaller studies of autism brains — one from 2011 by the same ...

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Johns Hopkins researchers identify new biological target for treating spinal muscular atrophy

lncRNA

Johns Hopkins researchers along with academic and drug industry investigators say they have identified a new biological target for treating spinal muscular atrophy. They report they have evidence that an experimental medicine aimed at this target works as a “booster” in conjunction with a drug called nusinersen that was recently FDA-approved to improve symptoms of the disorder in mice. In ...

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Research Reveals the Importance of Long Non-Coding RNA Regulating Cellular Processes

lncRNA

Scientific research over the past decade has concentrated almost exclusively on the 2 percent of the genome’s protein coding regions, virtually ignoring the other 98 percent, a vast universe of non-coding genetic material previously dismissed as nothing more than ‘junk.’ Now, a team led by investigators at Beth Israel Deaconess Medical Center (BIDMC) reveals that one type — called long ...

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Humira treatment restores dysregulated lncRNA gene networks

lncRNA

from Psoriasis News Today by Joana Fernandes – Researchers identified abnormal genetic pathways associated with psoriasis, some of which may be restored after treatment with Humira (adalimumab), according to a new study published in the journal BMC Genomics. In the study, “Network Analysis Of Psoriasis Reveals Biological Pathways And Roles For Coding And Long Non-Coding RNAs,” researchers observed that many pathways associated ...

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lncRNAs Neat1 and SAMMSON: similar, yet different anti-cancer targets

lncRNA

A team of researchers led by Chris Marine (VIB-KU Leuven) has shown that NEAT1, a long non-coding RNA, plays an important role in the survival of highly dividing cells – cancer cells in particular. The research has a striking similarity to earlier findings by the Marine lab about SAMMSON, a long non-coding RNA gene on which the growth of aggressive ...

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Junk food or junk genome?

lncRNA

from Laboratory News by Jose Ramon Bilbao and Ainara Castellanos-Rubio – As evidence pointing to the importance of non-coding regions of the genome mounts, a team from Spain discover a long non-coding RNA which plays a pivotal role in coeliac disease Coeliac disease (CD) is an immune-mediated enteropathy caused by ingested gluten that develops in genetically susceptible individuals. Nowadays, it ...

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CRISPR Deletion-Based Screen Identifies Functional Long Non-Coding RNAs

lncRNA

from GenomeWeb by Andrew Han – A new study published today in Nature Biotechnology turns high-throughput CRISPR/Cas9-based knockout screening towards long non-coding RNAs to find functional elements. A Chinese-American collaboration, led by first author Shiyou Zhu and senior author Wei Li  of Peking University and first author Wensheng Wei and senior author Xiaole Shirley Liu of the Dana-Farber Cancer Institute, ...

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