Commentary

Scientists discover lncRNA that could revert cellular ageing

lncrna

Researchers at Instituto de Medicina Molecular (iMM) João Lobo Antunes have found that manipulating a single RNA molecule is enough to revert cellular ageing. Throughout time all cells age gradually, contributing to the development of several diseases. Inducing cellular regeneration is one of the strategies used to fight diseases associated with cellular ageing. However, aged cells tend to be highly ...

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Researchers establish function of lncRNA in skin development and disease

Researchers from Case Western Reserve University School of Medicine have discovered how unusually long pieces of RNA work in skin cells. The RNA pieces, called “long non-coding RNAs” or “lncRNAs,” help skin cells modulate connective tissue proteins, like collagen, and could represent novel therapeutic targets to promote skin repair. In a recent Frontiers Genetics study, researchers identified specific lncRNAs that ...

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Living in an RNA world

lncrna

The central dogma postulates that genes are first copied into messenger RNAs, which are then decoded into proteins with the help of transfer RNAs and ribosomal RNAs. It has long been known that there is more to the world of RNA...

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The Long and Short of It – Long Non-Coding RNAs

lncRNA

from Biocompare by Gina Shaw – Human and other mammalian genomes pervasively transcribe tens of thousands of long non-coding RNAs (lncRNAs). The latest edition of data produced by the public research consortium GenCode (version #27) catalogs just under 16,000 lncRNAs in the human genome, producing nearly 28,000 transcripts; when other databases are included, more than 40,000 lncRNAs are known. These ...

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Many viruses activate a single RNA to enable successful infections

lncrna

from ARS Technica – Viruses co-opt one of a cell’s long noncoding RNAs to replicate A gene is a DNA sequence that encodes the instructions for when and where to make a particular protein. But most of the DNA in our genome—well over ninety percent—is not composed of genes. The argument over the role of this seemingly extraneous DNA has swung back and ...

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Female immune cells use lncRNA to keep their second X chromosome shut off

lncRNA

Autoimmune diseases tend to strike women more than men and having multiple X chromosomes could be the main reason why. While a process called X chromosome inactivation serves to balance out gene dosage between males and females, some genes on the “inactive X” chromosome in immune cells can sometimes escape this process, giving women an extra dose of immunity-related gene ...

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Researchers find novel lncRNA mechanism of resistance to anti-cancer drugs

lncrna

The targeted anti-cancer therapies cetuximab and panitumumab are mainstays of treatment for advanced colorectal cancer, the second leading cause of cancer-related deaths in the United States. However, many patients have tumors with genetic mutations that make them resistant to these anti-epidermal growth factor receptor (EGFR) monoclonal antibodies, or the cancers develop resistance during treatment. Researchers seeking to understand mechanisms of ...

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UTA researchers discover connection between low oxygen levels and the lncRNA HOTAIR

lncrna

University of Texas at Arlington researchers have established a link between hypoxia, a condition that reduces the flow of oxygen to tissues, and HOTAIR, a noncoding RNA or molecule that has been implicated in several types of cancer. RNA, or ribonucleic acid, is present in all living cells. Its primary role is to carry instructions from DNA. In a study ...

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Novel RNA Discoveries Could Improve Stem Cell Research

A recently described variety of RNA closely associated with gene expression was found to be largely cell-type specific, raising the possibility this variety of RNA sequences may be able to be used as a marker in stem cell research. Only about 20 percent of RNA codes for proteins, and the remaining 80 percent, called non-coding RNA, is thought to be ...

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