News

Scientists discover lncRNA that could revert cellular ageing

lncrna

Researchers at Instituto de Medicina Molecular (iMM) João Lobo Antunes have found that manipulating a single RNA molecule is enough to revert cellular ageing. Throughout time all cells age gradually, contributing to the development of several diseases. Inducing cellular regeneration is one of the strategies used to fight diseases associated with cellular ageing. However, aged cells tend to be highly ...

Read More »

Researchers establish function of lncRNA in skin development and disease

Researchers from Case Western Reserve University School of Medicine have discovered how unusually long pieces of RNA work in skin cells. The RNA pieces, called “long non-coding RNAs” or “lncRNAs,” help skin cells modulate connective tissue proteins, like collagen, and could represent novel therapeutic targets to promote skin repair. In a recent Frontiers Genetics study, researchers identified specific lncRNAs that ...

Read More »

Decoding critical long non-coding RNA in ovarian cancer

lncrna

Ovarian cancer is the most lethal gynecologic malignancy in the United States, resulting in an estimated 14,100 deaths and 22,500 new cases in 2017 alone. This high mortality is primarily caused by resistance to therapy and the diagnosis of ovarian cancer after it has already metastasized, which occurs in approximately 80 percent of patients. A new study from Sidney Kimmel ...

Read More »

Living in an RNA world

lncrna

The central dogma postulates that genes are first copied into messenger RNAs, which are then decoded into proteins with the help of transfer RNAs and ribosomal RNAs. It has long been known that there is more to the world of RNA...

Read More »

The Long and Short of It – Long Non-Coding RNAs

lncRNA

from Biocompare by Gina Shaw – Human and other mammalian genomes pervasively transcribe tens of thousands of long non-coding RNAs (lncRNAs). The latest edition of data produced by the public research consortium GenCode (version #27) catalogs just under 16,000 lncRNAs in the human genome, producing nearly 28,000 transcripts; when other databases are included, more than 40,000 lncRNAs are known. These ...

Read More »

Many viruses activate a single RNA to enable successful infections

lncrna

from ARS Technica – Viruses co-opt one of a cell’s long noncoding RNAs to replicate A gene is a DNA sequence that encodes the instructions for when and where to make a particular protein. But most of the DNA in our genome—well over ninety percent—is not composed of genes. The argument over the role of this seemingly extraneous DNA has swung back and ...

Read More »

Tel Aviv University researchers ID lncRNAs in the auditory system, take step toward curing deafness

lncrna

A new Tel Aviv University study solves a critical piece of the puzzle of human deafness by identifying the first group of long non-coding RNAs (lncRNAs) in the auditory system. “The research on long non-coding RNAs is crucial to understanding how gene expression and regulatory elements influence the auditory system,” says Prof. Karen Avraham, Vice Dean of TAU’s Sackler Faculty ...

Read More »

Female immune cells use lncRNA to keep their second X chromosome shut off

lncRNA

Autoimmune diseases tend to strike women more than men and having multiple X chromosomes could be the main reason why. While a process called X chromosome inactivation serves to balance out gene dosage between males and females, some genes on the “inactive X” chromosome in immune cells can sometimes escape this process, giving women an extra dose of immunity-related gene ...

Read More »

Researchers find novel lncRNA mechanism of resistance to anti-cancer drugs

lncrna

The targeted anti-cancer therapies cetuximab and panitumumab are mainstays of treatment for advanced colorectal cancer, the second leading cause of cancer-related deaths in the United States. However, many patients have tumors with genetic mutations that make them resistant to these anti-epidermal growth factor receptor (EGFR) monoclonal antibodies, or the cancers develop resistance during treatment. Researchers seeking to understand mechanisms of ...

Read More »