News

Johns Hopkins researchers identify new biological target for treating spinal muscular atrophy

lncRNA

Johns Hopkins researchers along with academic and drug industry investigators say they have identified a new biological target for treating spinal muscular atrophy. They report they have evidence that an experimental medicine aimed at this target works as a “booster” in conjunction with a drug called nusinersen that was recently FDA-approved to improve symptoms of the disorder in mice. In ...

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Research Reveals the Importance of Long Non-Coding RNA Regulating Cellular Processes

lncRNA

Scientific research over the past decade has concentrated almost exclusively on the 2 percent of the genome’s protein coding regions, virtually ignoring the other 98 percent, a vast universe of non-coding genetic material previously dismissed as nothing more than ‘junk.’ Now, a team led by investigators at Beth Israel Deaconess Medical Center (BIDMC) reveals that one type — called long ...

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UCSF CRISPR Study Reveals Unexpected Roles of Long Non-Coding RNAs

lncRNA

High-Throughput Screening Platform Finds that Distinct Non-Coding RNAs are Essential to the Growth of Different Cancer Cell Types UC San Francisco researchers have taken a major step toward understanding the function of the tens of thousands of human genes that do not code for proteins, a phenomenon considered one of the key remaining mysteries of the human genome. New findings ...

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Humira treatment restores dysregulated lncRNA gene networks

lncRNA

from Psoriasis News Today by Joana Fernandes – Researchers identified abnormal genetic pathways associated with psoriasis, some of which may be restored after treatment with Humira (adalimumab), according to a new study published in the journal BMC Genomics. In the study, “Network Analysis Of Psoriasis Reveals Biological Pathways And Roles For Coding And Long Non-Coding RNAs,” researchers observed that many pathways associated ...

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lncRNAs Neat1 and SAMMSON: similar, yet different anti-cancer targets

lncRNA

A team of researchers led by Chris Marine (VIB-KU Leuven) has shown that NEAT1, a long non-coding RNA, plays an important role in the survival of highly dividing cells – cancer cells in particular. The research has a striking similarity to earlier findings by the Marine lab about SAMMSON, a long non-coding RNA gene on which the growth of aggressive ...

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Junk food or junk genome?

lncRNA

from Laboratory News by Jose Ramon Bilbao and Ainara Castellanos-Rubio – As evidence pointing to the importance of non-coding regions of the genome mounts, a team from Spain discover a long non-coding RNA which plays a pivotal role in coeliac disease Coeliac disease (CD) is an immune-mediated enteropathy caused by ingested gluten that develops in genetically susceptible individuals. Nowadays, it ...

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CRISPR Deletion-Based Screen Identifies Functional Long Non-Coding RNAs

lncRNA

from GenomeWeb by Andrew Han – A new study published today in Nature Biotechnology turns high-throughput CRISPR/Cas9-based knockout screening towards long non-coding RNAs to find functional elements. A Chinese-American collaboration, led by first author Shiyou Zhu and senior author Wei Li  of Peking University and first author Wensheng Wei and senior author Xiaole Shirley Liu of the Dana-Farber Cancer Institute, ...

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lncRNA COOLAIR displays a striking resemblance to an RNA molecular machine

lncRNA

Los Alamos-U.K. collaboration unveils hidden molecular machinery in RNA processes A special stretch of ribonucleic acid (RNA) called COOLAIR is revealing its inner structure and function to scientists, displaying a striking resemblance to an RNA molecular machine, territory previously understood to be limited to the cells’ protein factory (the ‘ribosome’) and not a skill set given to mere strings of ...

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MIT biologists unravel lncRNA structure-to-function relationships

lncRNA

from MIT News by Anne Trafton – Several years ago, biologists discovered a new type of genetic material known as long noncoding RNA. This RNA does not code for proteins and is copied from sections of the genome once believed to be “junk DNA.” Since then, scientists have found evidence that long noncoding RNA, or lncRNA, plays roles in many ...

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Human natural antisense lncRNAs can up-regulate protein translation

lncRNA

One of the biggest surprises of the past decade of genomic studies was the discovery that, contrary to previous belief, the majority of the genome is not used to produce proteins. Initially, many scientists thought that these long non-coding RNAs were non-functional “noise,” but in recent studies, a growing fraction of these lncRNAs have been found to have regulatory functions. ...

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