News

lncRNAs take center stage at NCI RNA Biology 2017 symposium

rna-seq

The recent discovery of new classes of RNAs and the demonstration that alterations in RNA metabolism underlie numerous human cancers have resulted in enormous interest among CCR investigators in RNA Biology. In order to share the latest research in this exciting field, the CCR Initiative in RNA Biology held its second international symposium April 23-24, 2017, in Natcher Auditorium. With ...

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A blood test for multiple sclerosis? Expect one in late May

lncRNA

MedCityNews – The medical toolbox for treating multiple sclerosis (MS) has progressed in leaps and bounds over the last two decades, as highlighted by the recent approval of Ocrevus for the most severe and treatment-resistant form of the disease. Despite this success, the underlying disease mechanisms and triggers are not well understood. This makes diagnosis a challenge — with very high ...

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Could long non-coding RNAs be used as biomarkers for urothelial carcinoma?

exosomes

Bioanalysis Zone – Amy Craddock, Future Science Group – Collaborative research from medical faculties across Germany and Hungary has investigated the potential use of long non-coding RNAs as diagnostic and prognostic biomarkers for urothelial carcinoma. In previous studies, it has been identified that a number of long non-coding RNAs are overexpressed in urothelial carcinoma; as a result it has been ...

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lncRNA researcher at Stanford Medicine named Outstanding Investigator by the National Cancer Institute

lncRNA

The National Cancer Institute has named professor of dermatology HOWARD CHANG, MD as a recipient of the institute’s Outstanding Investigator Awards for 2016. Howard Chang The awards provide funding to investigators with outstanding records of productivity in cancer research. Recipients receive up to $600,000 each year for seven years to pursue or extend research projects of unusual potential. “This is a ...

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Translating the ribosome’s grim role

A large number of long noncoding RNAs (lncRNA) have been found associating with the ribosome, the protein-making machinery in the cytoplasm. What the so-called ‘noncoding’ RNAs are doing on the ribosome, whose main job is to translate RNA into protein, has puzzled the A*STAR researchers who discovered them. The answer could be macabre, suggest cell biologist, Leah Vardy, at the ...

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Linking lncRNA to autoimmune diseases

lncRNA

News Medical Life Sciences – An interview with Dr. Chase Spurlock, CEO, IQuity, conducted by April Cashin-Garbutt, MA (Cantab) What are long non-coding RNAs (lncRNAs) and how do they differ from messenger RNAs (mRNAs)? Well, the central dogma of biology states that DNA makes RNA and RNA makes proteins. However, there are many different types of RNAs, and only one ...

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Dietary anti-cancer compound may work by influence over lncRNAs

lncRNA

Researchers have discovered one of the reasons why broccoli may be good for your health.  They found that sulforaphane, a dietary compound from broccoli that’s known to help prevent prostate cancer, may work through its influence on long, non-coding RNAs. This is another step forward in a compelling new area of study on the underlying genetics of cancer development and ...

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Targeting lncRNA to reduce heart failure in pulmonary hypertension

lncrna

An article published in Experimental Biology and Medicine identifies a new signaling pathway that promotes heart failure in pulmonary hypertension.  The study, led by Dr. Matthias Brock, from the Division of Pulmonology, University Hospital of Zurich, University of Zurich in Switzerland, reports that inhibition of MALAT1, a long noncoding RNA, reduces heart hypertrophy in mice with pulmonary hypertension. Pulmonary hypertension ...

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Comprehensive Atlas of Long Noncoding RNAs Yields Surprising New Role

The FANTOM5 project reports nearly 20,000 functional lncRNAs in human Genetic Engineering News – The Central Dogma of molecular biology states that DNA encodes RNA, RNA encodes protein. While this process is certainly true for the vast majority gene regulatory functions, in recent years, scientists have discovered that this is by no means an exclusive process. In fact, studies examining ...

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New tool predicts the interaction of proteins and RNA

CRG Researchers developed Global Score, a method that allows, for the first time, to predict protein interactions with long non-coding RNAs. This algorithm helps scientists prioritize binding partners for experimental validation, which will contribute to our understanding of the role of long non-coding RNAs in normal cell function and in disease. Far from just reading the information contained in the ...

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