News

Linking lncRNA to autoimmune diseases

lncRNA

News Medical Life Sciences – An interview with Dr. Chase Spurlock, CEO, IQuity, conducted by April Cashin-Garbutt, MA (Cantab) What are long non-coding RNAs (lncRNAs) and how do they differ from messenger RNAs (mRNAs)? Well, the central dogma of biology states that DNA makes RNA and RNA makes proteins. However, there are many different types of RNAs, and only one ...

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Dietary anti-cancer compound may work by influence over lncRNAs

lncRNA

Researchers have discovered one of the reasons why broccoli may be good for your health.  They found that sulforaphane, a dietary compound from broccoli that’s known to help prevent prostate cancer, may work through its influence on long, non-coding RNAs. This is another step forward in a compelling new area of study on the underlying genetics of cancer development and ...

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Targeting lncRNA to reduce heart failure in pulmonary hypertension

lncrna

An article published in Experimental Biology and Medicine identifies a new signaling pathway that promotes heart failure in pulmonary hypertension.  The study, led by Dr. Matthias Brock, from the Division of Pulmonology, University Hospital of Zurich, University of Zurich in Switzerland, reports that inhibition of MALAT1, a long noncoding RNA, reduces heart hypertrophy in mice with pulmonary hypertension. Pulmonary hypertension ...

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Comprehensive Atlas of Long Noncoding RNAs Yields Surprising New Role

The FANTOM5 project reports nearly 20,000 functional lncRNAs in human Genetic Engineering News – The Central Dogma of molecular biology states that DNA encodes RNA, RNA encodes protein. While this process is certainly true for the vast majority gene regulatory functions, in recent years, scientists have discovered that this is by no means an exclusive process. In fact, studies examining ...

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New tool predicts the interaction of proteins and RNA

CRG Researchers developed Global Score, a method that allows, for the first time, to predict protein interactions with long non-coding RNAs. This algorithm helps scientists prioritize binding partners for experimental validation, which will contribute to our understanding of the role of long non-coding RNAs in normal cell function and in disease. Far from just reading the information contained in the ...

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Researchers at Imperial College London have found that so-called ‘junk DNA’ could play a role in diabetes

lncrna

The human genome is enormous, containing billions of ‘letters’ of genetic code. But among the thousands of genes which code for vital proteins, hidden in plain sight are much vaster chunks of non-coding junk DNA, previously thought to have no function. Shining the spotlight on these dark, unexplored regions of the genome, an international team led by scientists at Imperial ...

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CRISPR-Mediated Interference (CRISPRi) of Long Non-Coding RNA (lncRNA)

lncRNA

by Jerry Zon More Methodology from CRISPR Mania lncRNA Function Blocked by CRISPRi Mysteries of lncRNA Can Now be Deciphered by CRISPRi This blog is about yet another example of a powerful new methodology spawned by intense scientific interest in using CRISPR-related technologies. This near mania for all things CRISPR is reflected by there being ~5,000 (!) publications already in ...

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A “coding” long non-coding RNA

lncRNA

from Genetic Engineering News Although long noncoding RNAs (lncRNAs) are by definition noncoding, they are known to encode disproportionately short molecules—mere polypeptides, not proteins. Whether these polypeptides matter very much is another question. They could represent nothing more than transcriptional noise, or they could be—as a new study suggests—functionally relevant. In the new study, scientists based at Beth Israel Deaconess ...

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IQuity lands $150K NIH grant for autoimmune disease research

exosomes

Nashville-based IQuity — which analyzes RNA data to develop tools that help physicians diagnose autoimmune diseases — has received a $150,000 grant from the National Institutes of Health’s Small Business Innovation Research program. The grant will help fund IQuity’s ongoing research into long non-coding RNAs and their usefulness in distinguishing fibromyalgia from rheumatic diseases including rheumatoid arthritis and lupus, according ...

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Of the RNAs expressed at different levels in the autism brains, 60 are long non-coding RNAs

exosome

from Spectrum News by Nicholette Zeliadt The brains of people with autism show a distinct molecular signature, according to the largest-yet postmortem study of people with the condition1. The signature reflects alterations in how genes are pieced together and expressed. The findings confirm and extend those from two smaller studies of autism brains — one from 2011 by the same ...

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