Featured lncRNA

Long noncoding RNA GAPLINC promotes invasion in colorectal cancer

lncRNA

This study aimed to investigate the role of long noncoding RNAs (lncRNAs) in the metastasis of colorectal cancer (CRC). Metastasis is an important prognostic factor of CRC, and lncRNAs have been implicated in tumor proliferation and metastasis. Genome-wide lncRNA expression patterns in metastatic lymph nodes compared with paired normal lymph nodes of CRC were assessed by microarray analysis. Gastric adenocarcinoma ...

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NEAT1 is Required for Survival of Breast Cancer Cells

Increasing evidence shows that long noncoding RNAs (lncRNAs) have important roles in the regulation of multiple cellular processes, including cell division, cell growth, and apoptosis, as well as cancer metastasis and neurological disease progression; however, the mechanism of how lncRNAs regulate these processes is not well established. In this study, researchers from the Chinese Academy of Sciences demonstrated that downregulating ...

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Featured lncRNA – Smooth Muscle Enriched Long Non-Coding RNA (SMILR)

lncRNA

Using RNA-sequencing, researchers from the University of Glasgow identified >300 lncRNAs whose expression was altered in human saphenous vein (HSV) VSMCs following stimulation with IL1α and PDGF. They focused on a novel lncRNA (Ensembl: RP11-94A24.1) which they termed smooth muscle induced lncRNA enhances replication (SMILR). Following stimulation, SMILR expression was increased in both the nucleus and cytoplasm, and was detected ...

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Featured lncRNA – RZE1

lncRNA

In the fungal pathogen Cryptococcus neoformans, the switch from yeast to hypha is an important morphological process preceding the meiotic events during sexual development. Morphotype is also known to be associated with cryptococcal virulence potential. Previous studies identified the regulator Znf2 as a key decision maker for hypha formation and as an anti-virulence factor. By a forward genetic screen, researchers ...

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Featured lncRNA – PCAT5

lncRNA

Castration-resistant prostate cancer (CRPC) that arise after the failure of androgen blocking therapies cause most of the deaths from prostate cancer (PC), intensifying the need to fully understand CRPC pathophysiology. A team led by researchers at MD Anderson Cancer Center characterized the transcriptomic differences between untreated PC and locally recurrent CRPC and they report the identification of 145 previously unannotated ...

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Featured lncRNA – PVT1

lncRNA

It is becoming increasingly clear that short and long noncoding RNAs critically participate in the regulation of cell growth, differentiation, and (mis)function. However, while the functional characterization of short non-coding RNAs has been reaching maturity, there is still a paucity of well characterized long noncoding RNAs, even though large studies in recent years are rapidly increasing the number of annotated ...

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Featured lncRNA – DEANR1

lncRNA

Long non-coding RNAs (lncRNAs) regulate diverse biological processes, including cell lineage specification. Here, researchers from Harvard Medical School report transcriptome profiling of human endoderm and pancreatic cell lineages using purified cell populations. Analysis of the data sets allows us to identify hundreds of lncRNAs that exhibit differentiation-stage-specific expression patterns. As a first step in characterizing these lncRNAs, they focus on an ...

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Featured lncRNA – acal

lncRNA

Changes in cell shape affect many critical cellular and bodily processes, like wound healing and developmental events, and when gone awry, metastatic processes in cancer. Evolutionarily conserved signaling pathways govern regulation of these cellular changes. The Jun-N-terminal kinase pathway regulates cell stretching during wound healing and normal development. An extensively studied developmental process is embryonic dorsal closure in fruit flies, ...

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Featured Long Non-coding RNA – LOC401317

lncRNA

Recent studies have revealed that long non-coding RNAs participate in all steps of cancer initiation and progression by regulating protein-coding genes at the epigenetic, transcriptional, and post-transcriptional levels. Long non-coding RNAs are in turn regulated by other genes, forming a complex regulatory network. The regulation networks between the p53 tumor suppressor and these RNAs in nasopharyngeal carcinoma remains unclear. Here, ...

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Featured long non-coding RNA – meiRNA

lncRNA

Long non-coding RNAs (lncRNAs) play key roles in the formation of nuclear bodies. In the fission yeast Schizosaccharomyces pombe, a lncRNA species termed meiRNA forms a nuclear dot structure at its own genetic locus, the sme2 locus, with its protein-binding partner Mei2. This dot structure, called Mei2 dot, promotes the progression of meiosis by suppressing Mmi1, a crucial factor involved ...

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