Reader Contributions

A new lncRNA in adenocarcinoma is associated with overall survival

lncRNA

It is increasingly evident that non-coding RNAs play a significant role in tumour development. However, we still have a limited knowledge of the clinical significance of long non-coding RNAs (lncRNAs) in lung cancer. The FENDRR is a long coding RNA (also named FOXF1-AS1) located in the vicinity of the protein-coding gene FOXF1 at 16q24.1 chromosomal region. Researchers from the University of ...

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Post-doc position available – non-coding RNAs and skin wound healing

lncRNA

Karolinska Institutet, Institutionen för medicin, Solna The Department of Medicine, Solna, is one of the largest departments at Karolinska Institutet. The department consists of several units that are separated into different research groups. The core activities of the department are research, doctoral education and undergraduate education for medical and biomedical students. The research has three main profiles: allergy, cardiovascular medicine ...

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Post-doc position available to study novel lncRNAs

lncRNA

A post-doctoral position is available immediately to study novel lncRNAs in a well-funded laboratory at the University of Rochester School of Medicine and Dentistry.  The laboratory was the first to report on a human-specific lncRNA (SENCR) enriched in vascular cells and has been a leading cardiovascular lab in CRISPR genome editing.  The lab uses a broad palette of tools to ...

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Intersecting transcriptomic profiling technologies and long non-coding RNA function in lung adenocarcinoma

lncrna

Previously thought of as junk transcripts and pseudogene remnants, long non-coding RNAs (lncRNAs) have come into their own over the last decade as an essential component of cellular activity, regulating a plethora of functions within multicellular organisms. lncRNAs are now known to participate in development, cellular homeostasis, immunological processes, and the development of disease. With the advent of next generation ...

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lncRNA GAS5 and the efficacy of steroids

lncRNA

Glucocorticoids (GCs) are widely employed in inflammatory, autoimmune and neoplastic diseases, and, despite the introduction of novel therapies, remain the first-line treatment for inducing remission in inflammatory bowel disease (IBD). Given the high incidence of suboptimal response, associated with a significant number of side effects, that are particularly severe in paediatric patients, the identification of subjects that are most likely ...

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Neat1 is a p53-inducible lincRNA essential for transformation suppression

lncrna

The p53 gene is mutated in over half of all cancers, reflecting its critical role as a tumor suppressor. Although p53 is a transcriptional activator that induces myriad target genes, those p53-inducible genes most critical for tumor suppression remain elusive. Here, researchers at Stanford University School of Medicine leveraged p53 ChIP-seq (chromatin immunoprecipitation [ChIP] combined with high-throughput sequencing) and RNA-seq ...

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lncRNAs and MYC – An Intricate Relationship

lncrna

Long non-coding RNAs (lncRNAs) are emerging as important regulators of gene expression networks, acting either at the transcriptional level, by influencing histone modifications, or at the post-transcriptional level, by controlling mRNA stability and translation. Among the gene expression networks known to influence the process of oncogenic transformation, the one controlled by the proto-oncogene MYC is one of the most frequently ...

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Post-doc Position Available: Bioinformatics of lncRNA in Cardiac Regeneration

lncrna

The “Genomics of Long Non-Coding RNAs in Disease” Laboratory at the University of Bern has an opportunity for a Bioinformatics Postdoc. Diseases of the heart are the single greatest cause of death worldwide. Future regenerative therapies depend on understanding the molecular pathways underlying the development and differentiation of heart cells. We are excited about the role of lncRNAs in these ...

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Call for papers (Non-Coding RNA journal, MDPI)

lncRNA

ncRNA is a rapidly growing field in which new research methods are continuously appearing. With this Special Issue, we aim to collect a selection of articles on newly developed techniques of special interest for researchers in the ncRNA field. We will consider manuscripts that report on new experimental methods, as well as reviews of exceptional interest that focus on newly ...

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Researchers develop new CRISPR sgRNA design tool, demonstrate efficient CRISPR deletion of an enhancer and exonic fragment of the lncRNA MALAT1

lncRNA

CRISPR-Cas9 technology can be used to engineer precise genomic deletions with pairs of single guide RNAs (sgRNAs). This approach has been widely adopted for diverse applications, from disease modelling of individual loci, to parallelized loss-of-function screens of thousands of regulatory elements. However, no solution has been presented for the unique bioinformatic design requirements of CRISPR deletion. Researchers from the Centre for ...

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