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Gene regulation in the immune system by long noncoding RNAs

lncRNA

Long noncoding RNAs (lncRNAs) are emerging as critical regulators of gene expression in the immune system. Studies have shown that lncRNAs are expressed in a highly lineage-specific manner and control the differentiation and function of innate and adaptive cell types. Here, Stanford University researchers discuss mechanisms used by lncRNAs to regulate genes encoding products involved in the immune response, including direct ...

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MUSC researchers show how long non-coding RNA promotes tumor formation

A mechanism that pushes a certain gene to produce a non-coding form of RNA instead of its protein-coding alternative can promote the growth of cancer, report researchers at the Medical University of South Carolina (MUSC) in an article published online ahead of print on August 21, 2017 by Nature Cell Biology. The non-coding RNA soaks up a microRNA that prevents epithelial-to-mesenchymal ...

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Identification of an lncRNA‑miRNA‑mRNA interaction mechanism in breast cancer

lncRNA

Non‑coding RNAs serve important roles in regulating the expression of certain genes and are involved in the principal biological processes of breast cancer. The majority of studies have focused on defining the regulatory functions of long non‑coding RNAs (lncRNAs) and microRNAs (miRNAs/miRs), and few studies have investigated how lncRNAs and miRNAs are transcriptionally regulated. In the present study, based on ...

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Post-doc position available to study novel lncRNAs

lncRNA

A post-doctoral position is available immediately to study novel lncRNAs in a well-funded laboratory at the University of Rochester School of Medicine and Dentistry.  The laboratory was the first to report on a human-specific lncRNA (SENCR) enriched in vascular cells and has been a leading cardiovascular lab in CRISPR genome editing.  The lab uses a broad palette of tools to ...

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New Reference Text Published – Long Non Coding RNA Biology

lncRNA

In recent years, our functional understanding of the genome has changed dramatically. The discovery of pervasive transcription and the prevalence of noncoding RNAs (ncRNAs) have challenged the traditional definition of genes and what should be considered a functional region of the genome. Noncoding RNAs are defined as transcripts that do not encode proteins. Formally, this classification includes components of the ...

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Identification and characterization of a long non-coding RNA up-regulated during HIV-1 infection

lncRNA

Long non-coding RNAs (lncRNAs) are rapidly emerging as important regulators of a diverse array of cellular functions. Here, Columbia University researchers describe a meta-analysis of two independent RNA-seq studies to identify lncRNAs that are differentially expressed upon HIV-1 infection. Only three lncRNA genes exhibited altered expression of ≥ 2-fold in HIV-1-infected cells. Of these, the uncharacterized lncRNA LINC00173 was chosen ...

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Two novel lncRNAs discovered in human mitochondrial DNA using PacBio full-length transcriptome data

lncrna

In this study, researchers at Nankai University introduced a general framework to use PacBio full-length transcriptome sequencing for the investigation of mitochondrial RNAs. As a result, they produced the first full-length human mitochondrial transcriptome based on the public PacBio data and characterized the human mitochondrial transcriptome with more comprehensive and accurate information. Other results included the determination of the H-strand ...

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Intersecting transcriptomic profiling technologies and long non-coding RNA function in lung adenocarcinoma

lncrna

Previously thought of as junk transcripts and pseudogene remnants, long non-coding RNAs (lncRNAs) have come into their own over the last decade as an essential component of cellular activity, regulating a plethora of functions within multicellular organisms. lncRNAs are now known to participate in development, cellular homeostasis, immunological processes, and the development of disease. With the advent of next generation ...

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Long noncoding RNAs in cardiovascular disease, diagnosis, and therapy

lncrna

Long noncoding RNAs (lncRNAs) have emerged as powerful regulators of nearly all biological processes. Their cell-type and tissue-specific expression in health and disease provides new avenues for diagnosis and therapy. This review highlights the role of lncRNAs that are involved in cardiovascular disease (CVD) with a special focus on cell types involved in cardiac injury and remodeling, vascular injury, angiogenesis, ...

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Research Fellow Position Available – Mayo Medical School

lncRNA

Post Date: Aug 13, 2017 Job Type: Full time Start Date: – n/a – Salary: – n/a – Location: US – Minnesota – Rochester Job Reference: 75810BR Description Department: Biochemistry and Molecular Biology Specialty: Research A Life-Changing Career Position Summary: A postdoctoral research fellow position is available at the Mayo Medical School – Mayo Clinic (Rochester, Minnesota) to study the functions and mechanisms ...

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