Blog

Lncident – A Tool for Rapid Identification of Long Noncoding RNAs

lncrna

More and more studies have demonstrated that long noncoding RNAs (lncRNAs) play critical roles in diversity of biological process and are also associated with various types of disease. How to rapidly identify lncRNAs and messenger RNA is the fundamental step to uncover the function of lncRNAs identification. Researchers at Jilin University have devloped a novel method for rapid identification of ...

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Long Non-coding RNAs in Gastric Cancer: A True Relationship or miR Chance?

Long non-coding RNAs (lncRNAs) are gradually drawing the attention of the cancer research community due to their pivotal involvement in tumorigenesis and tumor progression. These non-protein coding, >200 nucleotides long transcripts are aberrantly expressed in the majority of human malignancies, including gastric cancer (GC). The discovery that lncRNAs are severely deregulated across different human malignancies has prompted the pursuit of ...

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Linking lncRNA to autoimmune diseases

lncRNA

News Medical Life Sciences – An interview with Dr. Chase Spurlock, CEO, IQuity, conducted by April Cashin-Garbutt, MA (Cantab) What are long non-coding RNAs (lncRNAs) and how do they differ from messenger RNAs (mRNAs)? Well, the central dogma of biology states that DNA makes RNA and RNA makes proteins. However, there are many different types of RNAs, and only one ...

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Post-doc position available – post-transcriptional roles of candidate long noncoding RNAs

lncRNA

Research Fellow Vacancy Ref: : 039227 Closing Date : 14-Apr-2017 Contact Person : IGMM HR Contact Number : 0131 651 8685 Contact Email : igmmhr@igmm.ed.ac.uk We are looking for a self-motivated, enthusiastic Research Fellow to join the group of Professor Chris Ponting. Job Purpose You would be joining an internationally successful research group who are investigating the post-transcriptional roles of ...

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Non-Coding RNAs – New Players in Skin Wound Healing

lncRNA

Significance: Wound healing is a basic physiological process that is utilized to keep the integrity of the skin. Impaired wound repair, such as chronic wounds and pathological scars, presents a major health and economic burden worldwide. To date, efficient targeted treatment for these wound disorders is still lacking, which is largely due to our limited understanding of the biological mechanisms ...

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Dietary anti-cancer compound may work by influence over lncRNAs

lncRNA

Researchers have discovered one of the reasons why broccoli may be good for your health.  They found that sulforaphane, a dietary compound from broccoli that’s known to help prevent prostate cancer, may work through its influence on long, non-coding RNAs. This is another step forward in a compelling new area of study on the underlying genetics of cancer development and ...

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IntNetLncSim – an integrative network analysis method to infer human lncRNA functional similarity

Increasing evidence indicated that long non-coding RNAs (lncRNAs) were involved in various biological processes and complex diseases by communicating with mRNAs/miRNAs each other. Exploiting interactions between lncRNAs and mRNA/miRNAs to lncRNA functional similarity (LFS) is an effective method to explore function of lncRNAs and predict novel lncRNA-disease associations. Researchers from Harbin Medical University have proposed an integrative framework, IntNetLncSim, to ...

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Targeting lncRNA to reduce heart failure in pulmonary hypertension

lncrna

An article published in Experimental Biology and Medicine identifies a new signaling pathway that promotes heart failure in pulmonary hypertension.  The study, led by Dr. Matthias Brock, from the Division of Pulmonology, University Hospital of Zurich, University of Zurich in Switzerland, reports that inhibition of MALAT1, a long noncoding RNA, reduces heart hypertrophy in mice with pulmonary hypertension. Pulmonary hypertension ...

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The Influence of microRNAs and Long Non-Coding RNAs in Cancer Chemoresistance

lncRNA

Innate and acquired chemoresistance exhibited by most tumours exposed to conventional chemotherapeutic agents account for the majority of relapse cases in cancer patients. Such chemoresistance phenotypes are of a multi-factorial nature from multiple key molecular players. The discovery of the RNA interference pathway in 1998 and the widespread gene regulatory influences exerted by microRNAs (miRNAs) and other non-coding RNAs have ...

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Post-doc Position Available – Structure and Mechanisms of Gene-regulatory Noncoding RNAs

lncRNA

A fully funded postdoctoral position (up to 5 years) is available in the Structural Biology of Noncoding RNAs and Ribonucleoproteins Section, Laboratory of Molecular Biology (LMB), NIDDK, in NIH’s vibrant main campus in Bethesda, MD near Washington DC. The lab addresses a widening gap between the accelerated discovery and functional description of the noncoding transcriptome, and a paucity of 3D ...

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