Blog

PLPIHS – prediction of lncRNA-protein interactions using HeteSim scores

lncRNA

Massive studies have indicated that long non-coding RNAs (lncRNAs) are critical for the regulation of cellular biological processes by binding with RNA-related proteins. However, only a few experimentally supported lncRNA-protein associations have been reported. Existing network-based methods are typically focused on intrinsic features of lncRNA and protein but ignore the information implicit in the topologies of biological networks associated with ...

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The Diversity of Long Noncoding RNAs and Their Generation

Long noncoding RNAs (lncRNAs) are emerging as potential key regulators in gene expression networks and exhibit a surprising range of shapes and sizes. Several distinct classes of lncRNAs are transcribed from different DNA elements, including promoters, enhancers, and intergenic regions in eukaryotic genomes. Additionally, others are derived from long primary transcripts with noncanonical RNA processing pathways, generating new RNA species ...

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LncRNA Transcriptional Control of Inflammatory Responses

lncRNA

Long non-coding RNAs (lncRNAs) have emerged as potential key regulators of the inflammatory response, particularly by modulating the transcriptional control of inflammatory genes. LncRNAs may act as an enhancer or suppressor to inflammatory transcription, function as scaffold molecules through interactions with RNA-binding proteins in chromatin remodeling complexes, and modulate dynamic and epigenetic control of inflammatory transcription in a gene-specific and ...

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Post-doc Position Available – Structure And Mechanisms Of Cellular And Viral Long Noncoding RNAs And RNPs

lncRNA

National Institute Of Diabetes And Digestive And Kidney Diseases NIH Position Description:  A fully funded postdoctoral position (up to 5 years) is available in the Structural Biology of Noncoding RNAs and Ribonucleoproteins Section, Laboratory of Molecular Biology (LMB), NIDDK, in NIH’s vibrant main campus in Bethesda, MD near Washington DC. The lab addresses a widening gap between the accelerated discovery ...

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Microarray profiling identifies long noncoding RNAs functionally involved in neurogenesis

lncRNA

The denervated hippocampus provides a proper microenvironment for the survival and neuronal differentiation of neural progenitors. While thousands of lncRNAs were identified, only a few lncRNAs that regulate neurogenesis in the hippocampus are reported. Researchers from Nantong University aimed to perform microarray expression profiling to identify long noncoding RNAs (lncRNAs) that might participate in the hippocampal neurogenesis, and investigate the potential ...

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Identification and prioritization of long non-coding RNAs associated with autism

Genetic studies have identified many risk loci for autism spectrum disorder (ASD) although causal factors in the majority of cases are still unknown. Currently, known ASD risk genes are all protein-coding genes; however, the vast majority of transcripts in humans are non-coding RNAs (ncRNAs) which do not encode proteins. Recently, long non-coding RNAs (lncRNAs) were shown to be highly expressed ...

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Identification and validation long non-coding RNAs of oral squamous cell carcinoma by bioinformatics method

lncRNA

Gene markers of oral squamous cell carcinoma (OSCC) have great significance on early diagnosis and treatment of clinical oral cancer. In this study, researchers from the Children Hospital of Chongqing Medical University used RNA-Seq data from OSCC patients and filtered differentially-expressed long non-coding RNA (lncRNA) to further clarify the molecular mechanism. First, they downloaded datasets of OSCC from National Center ...

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Postdoc position available – The mechanistic function and molecular structure of long noncoding RNAs

lncRNA

In the Pyle laboratory at Yale University (www.pylelab.org), we use a combination of cell biology and structural biology techniques to explore the architectural features and functions of large noncoding RNA molecules that control RNA splicing, transcription, pathogenicity, and gene expression. We are looking for highly motivated postdoctoral candidates to conduct pioneering work on the structural and functional characterization of long ...

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The lncRNA AK144841 could contribute to molecular cascades leading to tumor development

lncRNA

Keratinocyte-derived cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer. Although some of the early events involved in this pathology have been identified, the subsequent steps leading to tumor development are poorly defined. Researchers from Universite Cote d Azur demonstrate here that the development of mouse tumors induced by the concomitant application of a carcinogen and a ...

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Post-doc Position Available – RNA Research

lncRNA

Job Title: Postdoctoral Associate (RNA Research) Pay Grade: r5 Pay Band Min / Max:  – Position Number: P100005691 Department / Hospital: Biochemistry & Molecular Biology 11 -STA   The University of Miami Miller School of Medicine’s Department of Biochemistry and Molecular Biology has an opportunity for a Post-Doctoral Associate under the supervision of Dr. Stephen Lee, Professor of Biochemistry and Molecular Biology. Research for ...

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