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Extracellular vesicle associated long non-coding RNAs functionally enhance cell viability

Cells communicate with one another to create microenvironments and share resources. One avenue by which cells communicate is through the action of exosomes. Exosomes are extracellular vesicles that are released by one cell and taken up by neighbouring cells. But how exosomes instigate communication between cells has remained largely unknown. Researchers from the University of New South Wales present evidence ...

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Post-doc Position Available – Molecular Mechanisms of Gene Regulation

lncRNA

Position Title: Postdoctoral Research Associate_Calabrese Lab Vacancy ID: PDS001253 Department: Pharmacology – 424001 Position Type: Postdoctoral Scholar Full-time/Part-time: Full Time FTE: 1.0 Estimated Duration of Appointment: 12 Months Posting Open Date: 03/02/2016 Open Until Filled: Yes Work Location: Chapel Hill, NC Position Summary The Calabrese laboratory is seeking a postdoctoral fellow to study molecular mechanisms of gene regulation induced by ...

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Request for contributions to a special edition on lncRNA

lncRNA

Research Topic – Roles of Long Non-Coding RNAs in Embryonic Development and Cellular Homeostasis Advances in genomics over the past two decades have established that more than two thirds of the eukaryotic genome is pervasively transcribed, while just >2% codes for protein. Intriguingly, the degree of organismal complexity appears proportional to the transcribed non-coding portion of the genome. The majority ...

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LncRNAs and miRNAs – potential biomarkers and therapeutic targets for prostate cancer

Prostate cancer (PCa) is the second lethal disease for men in western countries. Although androgen receptor (AR) signaling has been widely investigated, noncoding RNAs (ncRNAs), deficient of open reading frame, have also received considerable attention. Growing studies showed that the aberrant ncRNAs expression contributed to cell proliferation, metastasis and drug resistance in PCa. Therefore, therapeutically targeting ncRNAs may synergize androgen ...

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KTCNlncDB – a first platform to investigate lncRNAs expressed in human keratoconus and non-keratoconus corneas

lncRNA

Keratoconus (KTCN, OMIM 148300) is a degenerative eye disorder characterized by progressive stromal thinning that leads to a conical shape of the cornea, resulting in optical aberrations and even loss of visual function. The biochemical background of the disease is poorly understood, which motivated researchers from the Medical University of Warsaw to perform RNA-Seq experiment, aimed at better characterizing the ...

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Effective knockdown of Drosophila long noncoding RNAs by CRISPR interference.

lncRNA

Ji-Long Liu (Univ Oxford) presents ‘Effective knockdown of Drosophila long noncoding RNAs by CRISPR interference.’ A presentation at the ‘Techniques & Resources’ session of the Annual Drosophila Research Conference at The Allied Genetics Conference, July 13-17, 2016, Orlando, Florida. Read the abstract: http://www.genetics-gsa.org/genetics/… For more presentations from #TAGC16 visit: http://www.genetics-gsa.org/tagcvideos or browse the playlists at: https://www.youtube.com/user/Genetics… More on #TAGC16: http://www.genetics2016.org/ ...

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LincSNP 2.0 – an updated database for linking disease-associated SNPs to human long non-coding RNAs

lncrna

Researchers from Harbin Medical University describe LincSNP 2.0, an updated database that is used specifically to store and annotate disease-associated single nucleotide polymorphisms (SNPs) in human long non-coding RNAs (lncRNAs) and their transcription factor binding sites (TFBSs). In LincSNP 2.0, the researchers have updated the database with more data and several new features, including: expanding disease-associated SNPs in human lncRNAs; ...

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Johns Hopkins researchers identify new biological target for treating spinal muscular atrophy

lncRNA

Johns Hopkins researchers along with academic and drug industry investigators say they have identified a new biological target for treating spinal muscular atrophy. They report they have evidence that an experimental medicine aimed at this target works as a “booster” in conjunction with a drug called nusinersen that was recently FDA-approved to improve symptoms of the disorder in mice. In ...

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FEELnc – a tool for long non-coding RNA annotation

lncRNA

Whole transcriptome sequencing (RNA-seq) has become a standard for cataloguing and monitoring RNA populations. One of the main bottlenecks, however, is to correctly identify the different classes of RNAs among the plethora of reconstructed transcripts, particularly those that will be translated (mRNAs) from the class of long non-coding RNAs (lncRNAs). Here, researchers from University Rennes1 present FEELnc (FlExible Extraction of ...

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Visualizing the secondary and tertiary architectural domains of lncRNA RepA

lncRNA

Long noncoding RNAs (lncRNAs) are important for gene expression, but little is known about their structures. RepA is a 1.6-kb mouse lncRNA comprising the same sequence as the 5′ region of Xist, including A and F repeats. It has been proposed to facilitate the initiation and spread of X-chromosome inactivation, although its exact role is poorly understood. To gain insight ...

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