Author Archives: lncRNA Administrator

Prostate cancer-associated lncRNAs

lncRNA

Long non-coding RNA (LncRNA) is defined as an RNA transcript that does not encode any protein, with a length longer than 200 nt. Based on the recent advances in high-throughput sequencing techniques, a large number of lncRNAs have been characterized as functional transcripts that play important roles in various biological processes as well as pathologic states. In a research field of ...

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Invitation to contribute – LncRNAs: From disease biomarkers to targeted therapeutics

lncRNA

As per genomic and the transcriptomic view, our index of genetic elements is brimming with long non-coding RNAs (lncRNAs). These have largely gained the attention of world scientific community and are currently in the spot light of the researchers. Since the research regarding these essential biomolecules is still in its infancy and the significant mysteries of lncRNA mechanisms still need ...

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Scientists discover lncRNA that could revert cellular ageing

lncrna

Researchers at Instituto de Medicina Molecular (iMM) João Lobo Antunes have found that manipulating a single RNA molecule is enough to revert cellular ageing. Throughout time all cells age gradually, contributing to the development of several diseases. Inducing cellular regeneration is one of the strategies used to fight diseases associated with cellular ageing. However, aged cells tend to be highly ...

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Identification of transposable elements contributing to tissue-specific expression of long non-coding RNAs

lncrna

It has been recently suggested that transposable elements (TEs) are re-used as functional elements of long non-coding RNAs (lncRNAs). This is supported by some examples such as the human endogenous retrovirus subfamily H (HERVH) elements contained within lncRNAs and expressed specifically in human embryonic stem cells (hESCs), as required to maintain hESC identity. There are at least two unanswered questions ...

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