Author Archives: lncRNA Administrator

NONCODEV5 – a comprehensive annotation database for long non-coding RNAs

lncRNA

NONCODE is a systematic database that is dedicated to presenting the most complete collection and annotation of non-coding RNAs (ncRNAs), especially long non-coding RNAs (lncRNAs). Since NONCODE 2016 was released two years ago, the amount of novel identified ncRNAs has been enlarged by the reduced cost of next-generation sequencing, which has produced an explosion of newly identified data. The third-generation ...

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University of Newcastle lands $675K to study lncRNA

lncRNA

In total, the University of Newcastle (UON) has attracted $12.2m in the latest round of National Health and Medical Research Council (NHMRC) funding to investigate some of the nation’s and world’s greatest health challenges. Senior Deputy Vice-Chancellor (Research and Innovation), Professor Kevin Hall, said the NHMRC’s support for Newcastle’s researchers was testament to the University’s reputation for conducting world-class research. ...

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Circulating lncRNAs Serve as Diagnostic Markers for Hepatocellular Carcinoma

lncRNA

Circulating (serous or plasmic) long non-coding RNA (lncRNA) as biomarkers for predicting the diagnosis or prognosis of human disease have been well documented. Due to the sensibility or specificity limitation of Alpha Fetoprotein (AFP), a cluster lncRNAs were revealed as fingerprints for hepatocellular carcinoma (HCC). In this study, researchers at Huai’an First People’s Hospital enrolled all the reported circulating lncRNAs ...

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A new lncRNA in adenocarcinoma is associated with overall survival

lncRNA

It is increasingly evident that non-coding RNAs play a significant role in tumour development. However, we still have a limited knowledge of the clinical significance of long non-coding RNAs (lncRNAs) in lung cancer. The FENDRR is a long coding RNA (also named FOXF1-AS1) located in the vicinity of the protein-coding gene FOXF1 at 16q24.1 chromosomal region. Researchers from the University of ...

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The Dark Side of the Epitranscriptome – Chemical Modifications in Long Non-Coding RNAs

lncrna

The broad application of next-generation sequencing technologies in conjunction with improved bioinformatics has helped to illuminate the complexity of the transcriptome, both in terms of quantity and variety. In humans, 70-90% of the genome is transcribed, but only ~2% carries the blueprint for proteins. Hence, there is a huge class of non-translated transcripts, called long non-coding RNAs (lncRNAs), which have ...

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MNDR v2.0 – an updated resource of ncRNA-disease associations in mammals

lncRNA

Accumulating evidence suggests that diverse non-coding RNAs (ncRNAs) are involved in the progression of a wide variety of diseases. In recent years, abundant ncRNA-disease associations have been found and predicted according to experiments and prediction algorithms. Diverse ncRNA-disease associations are scattered over many resources and mammals, whereas a global view of diverse ncRNA-disease associations is not available for any mammals. ...

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Prediction of clinical outcome and survival in soft-tissue sarcoma using a ten-lncRNA signature

lncRNA

The prognostic value of long non-coding RNAs (lncRNAs) in patients with soft-tissue sarcoma has rarely been unraveled. Researchers from Guangxi Medical University set out to find a lncRNA signature to predict the clinical outcome and survival in soft-tissue sarcoma based on the high-throughput RNA-seq data from The Cancer Genome Atlas (TCGA) database. The lncRNAs which closely correlated with overall survival ...

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Post-doc position available – non-coding RNAs and skin wound healing

lncRNA

Karolinska Institutet, Institutionen för medicin, Solna The Department of Medicine, Solna, is one of the largest departments at Karolinska Institutet. The department consists of several units that are separated into different research groups. The core activities of the department are research, doctoral education and undergraduate education for medical and biomedical students. The research has three main profiles: allergy, cardiovascular medicine ...

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Genome-wide discovery of long intergenic noncoding RNAs

lncRNA

Long intergenic noncoding RNAs (lincRNAs) play a crucial role in many biological processes. The rat is an important model organism in biomedical research. Recent studies have detected rat lincRNA genes from several samples. However, identification of rat lincRNAs using large-scale RNA-seq datasets remains unreported. Herein, using more than 100 billion RNA-seq reads from 59 publications together with RefSeq and UniGene ...

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The multidimensional mechanisms of long noncoding RNA function

lncrna

A major shift in our understanding of genome regulation has emerged recently. It is now apparent that the majority of cellular transcripts do not code for proteins, and many of them are long noncoding RNAs (lncRNAs). Increasingly, studies suggest that lncRNAs regulate gene expression through diverse mechanisms. Researchers from the University of Navarra review emerging mechanistic views of lncRNAs in gene ...

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