Author Archives: lncRNA Administrator

The role of a new class of long noncoding RNAs transcribed from ultraconserved regions in cancer

lncRNA

Ultraconserved regions (UCRs) represent a relatively new class of non-coding genomic sequences highly conserved between human, rat and mouse genomes. These regions can reside within exons of protein-coding genes, despite the vast majority of them localizes within introns or intergenic regions. Several studies have undoubtedly demonstrated that most of these regions are actively transcribed in normal cells/tissues, where they contribute ...

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The emerging molecular biology toolbox for the study of long noncoding RNA biology

lncRNA

Long noncoding RNAs (lncRNAs) have been implicated in many biological processes. However, due to the unique nature of lncRNAs and the consequential difficulties associated with their characterization, there is a growing disparity between the rate at which lncRNAs are being discovered and the assignment of biological function to these transcripts. Here researchers from the CSIR South Africa present a molecular biology ...

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Regulated expression of the lncRNA TERRA and its impact on telomere biology

lncrna

The telomere protects against genomic instability by minimizing the accelerated end resection of the genetic material, a phenomenon that results in severe chromosome instability that could favor the transformation of a cell by enabling the emergence of tumor-promoting mutations. Some mechanisms that avoid this fate, such as capping and loop formation, have been very well characterized; however, telomeric non-coding transcripts, ...

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Gene regulation of mammalian long non-coding RNA

lncRNA

RNA polymerase II (Pol II) transcribes two classes of RNAs, protein-coding and non-protein-coding (ncRNA) genes. ncRNAs are also synthesized by RNA polymerases I and III (Pol I and III). In humans, the number of ncRNA genes exceeds more than twice that of protein-coding genes. However, the history of studying Pol II-synthesized ncRNA is relatively short. Since early 2000s, important biological ...

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A Nucleus-localized Long Non-Coding RNA Enhances Drought and Salt Stress Tolerance

lncrna

Long non-coding RNAs (lncRNAs) affect gene expression through a wide range of mechanisms and are considered as important regulators in many essential biological processes. A large number of lncRNA transcripts have been predicted or identified in plants in recent years. However, the biological functions for most of them are still unknown. In this study, researchers from Texas A&M AgriLife Research ...

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The Role of Long Non Coding RNAs in the Repair of DNA Double Strand Breaks

lncRNA

DNA double strand breaks (DSBs) are abrasions caused in both strands of the DNA duplex following exposure to both exogenous and endogenous conditions. Such abrasions have deleterious effect in cells leading to genome rearrangements and cell death. A number of repair systems including homologous recombination (HR) and non-homologous end-joining (NHEJ) have been evolved to minimize the fatal effects of these ...

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Post-doc Positions Available – Bioinformatics and Cancer Cell Biology

lncRNA

Job Description Postdoctoral Associate positions (Bioinformatics and Cancer Cell Biology) are available to study the role of non-coding RNAs (long noncoding RNA and microRNAs) in our laboratory at Sanford-Burnham Medical Discovery Institute, Orlando FL USA.  Several putative oncogenic and tumor suppressor non-coding RNAs have been identified ( Lee et al Science Advances 2017 3(5): e1602505, Mazar et al Mol. Cell. Biol. ...

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Novel RNA Discoveries Could Improve Stem Cell Research

A recently described variety of RNA closely associated with gene expression was found to be largely cell-type specific, raising the possibility this variety of RNA sequences may be able to be used as a marker in stem cell research. Only about 20 percent of RNA codes for proteins, and the remaining 80 percent, called non-coding RNA, is thought to be ...

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Long noncoding RNAs coordinate functions between mitochondria and the nucleus

lncRNA

In animal cells, mitochondria are the primary powerhouses and metabolic factories. They also contain genomes and can produce mitochondrial-specific nucleic acids and proteins. To maintain homeostasis of the entire cell, an intense cross-talk between mitochondria and the nucleus, mediated by encoded noncoding RNAs (ncRNAs), as well as proteins, is required. Long ncRNAs (lncRNAs) contain characteristic structures, and they are involved ...

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