Monthly Archives: April 2014

A Network Based Method for Analysis of lncRNA-Disease Associations and Prediction of lncRNAs Implicated in Diseases

Increasing evidence has indicated that long non-coding RNAs (lncRNAs) are implicated in and associated with many complex human diseases. Despite of the accumulation of lncRNA-disease associations, only a few studies had studied the roles of these associations in pathogenesis. In this paper, researchers at Xidian University investigated lncRNA-disease associations from a network view to understand the contribution of these lncRNAs ...

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A Network Based Method for Analysis of lncRNA-Disease Associations and Prediction of lncRNAs Implicated in Diseases

Increasing evidence has indicated that long non-coding RNAs (lncRNAs) are implicated in and associated with many complex human diseases. Despite of the accumulation of lncRNA-disease associations, only a few studies had studied the roles of these associations in pathogenesis. In this paper, researchers at Xidian University investigated lncRNA-disease associations from a network view to understand the contribution of these lncRNAs ...

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An intragenic long noncoding RNA interacts epigenetically with the RUNX1 promoter and enhancer chromatin DNA in hematopoietic malignancies

lncRNA

RUNX1, a master regulator of hematopoiesis, is the most commonly perturbed target of chromosomal abnormalities in hematopoietic malignancies. The t(8;21) translocation is found in 30%-40% of cases of acute myeloid leukemia (AML). Recent whole-exome sequencing also reveals mutations and deletions of RUNX1 in some solid tumors. Researchers from Jilin University, China describe a RUNX1-intragenic long noncoding RNA ROPNR that is ...

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Species-specific alternative splicing leads to unique expression of sno-lncRNAs

Intron-derived long noncoding RNAs with snoRNA ends (sno-lncRNAs) are highly expressed from the imprinted Prader-Willi syndrome (PWS) region on human chromosome 15. However, sno-lncRNAs from other regions of the human genome or from other genomes have not yet been documented. By exploring non-polyadenylated transcriptomes from human, rhesus and mouse, researchers at the Shanghai Institutes for Biological Sciences have systematically annotated ...

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Species-specific alternative splicing leads to unique expression of sno-lncRNAs

Intron-derived long noncoding RNAs with snoRNA ends (sno-lncRNAs) are highly expressed from the imprinted Prader-Willi syndrome (PWS) region on human chromosome 15. However, sno-lncRNAs from other regions of the human genome or from other genomes have not yet been documented. By exploring non-polyadenylated transcriptomes from human, rhesus and mouse, researchers at the Shanghai Institutes for Biological Sciences have systematically annotated ...

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Role of the lncRNA-p53 regulatory network in cancer

lncRNA

Advances in functional genomics have led to discovery of a large group of previous uncharacterized long non-coding RNAs (lncRNAs). Emerging evidence indicates that lncRNAs may serve as master gene regulators through various mechanisms. Dysregulation of lncRNAs is often associated with a variety of human diseases including cancer. Of significant interest, recent studies suggest that lncRNAs participate in the p53 tumor ...

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Everything old is new again: (linc)RNAs make proteins!

lncRNA

Conventional protein-coding genes account for only a fraction of the RNA transcribed in animal genomes. Many of us grew up thinking that RNAs came in two flavours: those with protein-coding capacity and non-coding RNAs with structural roles, in the form of ribosomal RNAs, tRNAs, snoRNAs, etc. Interest in other forms of long non-coding RNAs (lincRNAs) has been growing over the ...

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Species-specific alternative splicing leads to unique expression of sno-lncRNAs

Intron-derived long noncoding RNAs with snoRNA ends (sno-lncRNAs) are highly expressed from the imprinted Prader-Willi syndrome (PWS) region on human chromosome 15. However, sno-lncRNAs from other regions of the human genome or from other genomes have not yet been documented. By exploring non-polyadenylated transcriptomes from human, rhesus and mouse, we have systematically annotated sno-lncRNAs expressed in all three species. In ...

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Featured long non-coding RNA – SENCR

There is little insight into whether and how lncRNAs effect human vascular cell phenotypes.  Now, researchers at the University of Rochester School of Medicine and Dentistry have performed RNA sequencing in human coronary artery smooth muscle cells and discovered a novel lncRNA called SENCR.  SENCR is most abundant in vascular smooth muscle cells and endothelial cells.  SENCR is a low copy, cytoplasmic ...

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A short guide to long non-coding RNA gene nomenclature

The HUGO Gene Nomenclature Committee (HGNC) is the only organisation authorised to assign standardised nomenclature to human genes. Of the 38,000 approved gene symbols in the database (www.genenames.org), the majority represent protein-coding (pc) genes; however, also named are pseudogenes, phenotypic loci, some genomic features, and to date have named more than 8,500 human non-protein coding RNA (ncRNA) genes and ncRNA ...

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